This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $223,622 to The University of Texas Health Science Center at San Antonio to conduct research on the pathogenic effects of senescent cells on their microenvironments and their role in human brain aging. The study aims to identify molecular changes in the microenvironment of senescent neurons compared to healthy neurons, as well as their specific role in neuronal death in brain aging and...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will provide $460,625 to the University of Massachusetts Medical School to dissect the role of cellular senescence pathways in the pathogenesis of Alzheimer's disease (AD). The project aims to use human induced pluripotent stem cell (iPSC)-based AD models to independently investigate the impact of the p53/p21 and p16 senescence pathways on AD-related cellular pathologies in differentiated cortical...
This Project Grant award from the National Institute on Aging's Aging Research federal grant program (CFDA 93.866) provides $871,419 to the University of Washington to conduct research on the role of microglia, the brain's immune cells, in the pathogenesis of Alzheimer's disease. The research aims to characterize molecular profiles and spatial organization of microglia across the adult age spectrum, both with and without Alzheimer's disease, through single-nucleus RNA sequencing of over 5,000...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $772,581 to the University of California, San Diego to investigate the role of the SOX18 transcription factor in neurovascular dysfunction associated with Alzheimer's disease. The research aims to examine how downregulation of SOX18 in brain endothelial cells may contribute to impaired angiogenesis and blood-brain barrier formation observed in Alzheimer's patients. The project will leverage...
This Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research program) supports research to investigate the molecular mechanisms underlying the relationship between the proteins SORT1, NSG1, and NSG2, and their potential role in the pathology of Alzheimer's disease (AD) and frontotemporal dementia (FTD).
The $419,375 award, effective June 15, 2024 through May 31, 2026, will enable researchers at the University of New Mexico Health Sciences Center to: 1) correlate...
This $131,027 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will support research by The Leland Stanford Junior University to study neuronal proteostasis, the maintenance of protein health, during brain aging and Alzheimer's disease (AD). The principal investigator will use a novel in vivo protein tagging technique called BONCAT to examine changes in neuronal protein turnover in young versus aged and AD mouse models. The project aims to characterize...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) aims to generate a comprehensive atlas of neurovascular protein lifetimes in health, aging, and a tauopathy-based model of Alzheimer's disease. The $437,875 award provides funding to researchers at the University of California, San Diego to employ stable isotope labeling in mammals (SILAM) and mass spectrometry-based proteomics to quantify changes in neurovascular protein lifetimes during...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $254,250 to New York University School of Medicine to conduct a multiscale modeling study of brain aging and Alzheimer's disease (AD). The key objectives are to:
Develop a biologically relevant multi-scale model of brain aging using advanced diffusion MRI techniques to examine the roles of neuroinflammation and neurodegeneration. This will involve creating a large dataset by unifying...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $239,122 to Yale University to leverage computational and experimental models to study the impact of aging processes and Alzheimer's disease (AD) risk variants on brain function. The key objectives are to:
Develop a cell-type specific regulatory network model for normal brain aging and AD brain aging, integrating large-scale epigenomic and transcriptomic datasets.
Generate empirical data...
This Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research) provides $842,175 in funding to the J. David Gladstone Institutes, a non-profit biomedical research organization in San Francisco, CA. The award will support research to explore the role of the NOX2 enzyme in mediating Alzheimer's disease-related brain dysfunctions, including network hyperactivity, glucose hypometabolism, and accumulation of amyloid-beta and tau proteins. The research aims to assess the...