Project Grant HT9425261E208
- Federal Grant Award Summary The University of North Carolina at Chapel Hill received a $694,987 Project Grant from the Defense Health Agency (DHA) under the Military Medical Research and Development program (CFDA 12.420) for the project "Innovative Immunotherapeutics for Breast Cancer Treatment." The award, effective October 1, 2025, through September 30, 2028, supports research and development activities designed to advance innovative immunotherapy approaches for breast cancer...
- Federal Grant Award Summary The University of North Carolina at Chapel Hill received a $749,996 Project Grant from the Defense Health Agency under the Military Medical Research and Development program (CFDA 12.420) effective August 1, 2026, through July 31, 2029. The award supports research titled "Mapping Histologic and Molecular Divergence in Breast Cancer Metastasis," which aligns with the Defense Health Agency's commitment to advancing innovative biomedical research that transforms...
- Federal Project Grant Award Summary The University of North Carolina at Chapel Hill received a $500,000 Project Grant from the Defense Health Agency under the Military Medical Research and Development program (CFDA 12.420) to support a novel drug discovery approach for preventing posttraumatic osteoarthritis. The award, effective July 1, 2025 through June 30, 2027, represents a two-year research initiative conducted at UNC-CH's Chapel Hill, North Carolina location. The funding supports...
- Federal Grant Award Summary The University of Pittsburgh received a $1.144M project grant from the Defense Health Agency (DHA) under the Military Medical Research and Development program (CFDA 12.420) effective September 1, 2025, through August 31, 2028. This research initiative addresses overcoming immunotherapy resistance in acral melanoma, a critical oncology research priority within the DHA's comprehensive portfolio of biomedical research initiatives. The grant supports hypothesis-driven...
- Federal Grant Award Summary Wake Forest University Health Sciences received a $621,779 Project Grant from the Defense Health Agency (DHA) under the Military Medical Research and Development program (CFDA 12.420) effective April 1, 2026 through March 31, 2029. The award supports research titled "Modulating Immune Stress Pathways as a Strategy for CIPN Prevention and Cancer Management," which addresses chemotherapy-induced peripheral neuropathy (CIPN) prevention while advancing cancer...
- Federal Project Grant Award Summary Duke University's Office of Research Administration was awarded $845,250 by the Defense Health Agency under the Military Medical Research and Development program (CFDA 12.420) beginning July 1, 2025, through June 30, 2028. The project focuses on engineering T-cell receptor (TCR)-modified T cells designed to target human endogenous retroviruses for non-small cell lung cancer immunotherapy. This research initiative represents an advanced biomedical research...
- Federal Grant Award Summary The Defense Health Agency awarded the University of Colorado-Denver a $904,982 Project Grant effective June 1, 2026, through May 31, 2029, under the Military Medical Research and Development program (CFDA 12.420). The award supports research to investigate the use of unconventional immune cells in treating rare melanomas and understanding immunotherapy resistance. This research initiative aligns with the Defense Health Agency's mission to advance innovative biomedical...
- Federal Grant Award Summary Wake Forest University Health Sciences received a $627,944 Project Grant award from the Defense Health Agency (DHA) under the Military Medical Research and Development program (CFDA 12.420), effective April 1, 2026, through March 31, 2029. The award supports research focused on modulating immune stress pathways as a strategy for chemotherapy-induced peripheral neuropathy (CIPN) prevention and cancer management. This three-year initiative leverages the institution's...
- Federal Grant Award Summary The Defense Health Agency (DHA) awarded a $1,197,884 Project Grant to the University of California, San Diego under the Military Medical Research and Development program (CFDA 12.420) for the project titled "Mechanism Dissection and Model Development of Human PD1 in Melanoma." The award was issued on August 15, 2025, with a performance period extending through August 14, 2028. The research will be conducted at UC San Diego's La Jolla, California campus. This...
- Federal Project Grant Award Summary The University of Virginia received an $858,608 project grant from the Defense Health Agency (DHA) under the Military Medical Research and Development program (CFDA 12.420) for the period of August 15, 2025 through August 14, 2028. The award supports research into understanding how melanoma-cognate T-cell help enhances survival outcomes in melanoma vaccine interventions. This research initiative contributes to the DHA's broader mission of advancing...
The University of North Carolina at Chapel Hill received a $559,213 Project Grant from the Defense Health Agency under the Military Medical Research and Development program (CFDA 12.420) for the period June 1, 2026 through May 31, 2028. The award supports research investigating melanoma-mediated epigenetic reprogramming of dendritic cell progenitors as a mechanism of immunotherapy resistance. This research addresses a critical gap in understanding how melanoma tumors evade immune-based therapeutic interventions by examining molecular mechanisms that compromise dendritic cell function, which plays a central role in initiating anti-tumor immune responses. The research deliverables will advance knowledge of immunotherapy resistance in melanoma through basic and translational scientific investigation conducted at UNC-Chapel Hill's Chapel Hill, North Carolina location. Findings from this work have potential applications in developing strategies to overcome immunotherapy resistance and improving treatment outcomes for melanoma patients. The Defense Health Agency's Military Medical Research and Development program prioritizes hypothesis-driven biomedical research designed to transform healthcare for military service members and the American public through innovative medical solutions addressing critical health challenges, including cancer immunotherapy and precision medicine approaches relevant to this investigation.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $559.2k | 5/13/26 |