Project Grant HT94252510562

This federal Project Grant award from the National Center for Complementary and Integrative Health (NCCIH), under the Research and Training in Complementary and Integrative Health (CFDA 93.213) program, provides $863,500 to Rutgers, The State University of New Jersey to conduct research on the effect of dysbiotic gut microbiota on the transport of short-chain fatty acids and its relevance to autoimmune disorders. The key objectives are to elucidate the mechanism by which gut microbiome impacts...

This Project Grant award from the National Institute on Aging's (NIA) Aging Research program (CFDA 93.866) provides $630,905 to the University of Wisconsin-Madison to explore the role of the gut microbiome-derived metabolite imidazole propionate (IMP) in the progression of Alzheimer's disease (AD) and related dementias (ADRD). The central hypothesis is that IMP modulates AD and ADRD pathology by altering vascular endothelial function and blood-brain barrier permeability. The research will...

This federal Project Grant award of $808,380, provided by the National Institute on Minority Health and Health Disparities (NIMHD) under the Minority Health and Health Disparities Research program (CFDA 93.307), supports research by Dr. Holzhausen at The Johns Hopkins University to examine the impact of maternal weight status and preterm birth on vertical microbiome transmission patterns and childhood overweight/obesity. The project aims to build upon existing microbiome, metabolome, and...

This Project Grant award from the National Cancer Institute (CFDA 93.393 - Cancer Cause and Prevention Research) provides $426,425 to Baylor College of Medicine to conduct a pilot study examining the relationship between gut microbiome composition, metabolic dysfunction-associated steatotic liver disease (MASLD), and hepatocellular carcinoma (HCC). The key objectives of this 2-year study are to: 1) characterize baseline gut microbiome diversity associated with MASLD with and without HCC, 2)...

This Project Grant awarded by the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), will support research to investigate how the gut microbiome composition impacts gastrointestinal (GI) and central nervous system (CNS) function in a mouse model of autism spectrum disorder (ASD). The $430,375 award to the partnership between Henry Ford Health and Michigan State University Health Sciences will...

The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded Duke University a $241,500 Project Grant under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to study the regulation of metabolic diseases by the human commensal bacterium Clostridium immunis. The overarching goal is to determine the mechanism by which an exopolysaccharide (EPS) secreted by C. immunis decreases visceral adiposity, a key risk factor for type 2 diabetes and...

The National Institute on Aging (NIA) awarded a $405,849 Project Grant (CFDA 93.866 - Aging Research) to the Keck Graduate Institute of Applied Life Sciences to investigate the impact of obesity-induced hepatic amyloid beta dysregulation on Alzheimer's disease pathology. The key objectives are to: Examine the relationship between changes in peripheral and hepatic amyloid beta with brain amyloid beta load and Alzheimer's disease pathology in Alzheimer's disease mice fed a high-fat/high-sugar...

This $183,600 Project Grant awarded by the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) supports research conducted by the University of Utah to investigate the impact of dietary changes on the gut microbiome and its relationship to eosinophilic esophagitis (EoE). The 5-year research project aims to: 1) characterize the fecal microbial composition, gene expression, and metabolites associated with...

This federal Project Grant award from the National Institute of Environmental Health Sciences (NIEHS) under the Environmental Health program (CFDA 93.113) is supporting research at the University of Texas Medical Branch at Galveston (UTMB) to investigate the role of gut microbiome dysbiosis in trichloroethylene-mediated autoimmunity. The $158,157 award will fund a study to determine how exposure to the environmental contaminant trichloroethylene (TCE) impacts the gut microbiome and contributes...

This $325,139 federal Project Grant award, funded by the National Center for Advancing Translational Sciences (NCATS), 93.350 program, aims to examine the feasibility of using target-specific polyclonal antibodies to neutralize bioactive molecules in the gut microbiome. The primary goals are to 1) determine the impact of six proteins identified as overabundant in inflammatory gut disorders, and 2) evaluate the ability of immunoglobulin Y (IgY) antibodies to neutralize the physiological impacts...