This $2,504,526 Project Grant, awarded by the Defense Health Agency under the Military Medical Research and Development program (CFDA 12.420), supports research to develop novel GABA transaminase inhibitors that can cross the blood-brain barrier and treat hyperglycemia, hyperinsulinemia, and insulin resistance. The primary awardee is the University of Arizona, which will collaborate with the University of Florida on this 4-year effort. The University of Florida will receive a $732,014 sub-grant to assist with the development of these blood-brain barrier impenetrable GABA transaminase inhibitors. This research aims to provide new treatment options for addressing these medical conditions that disproportionately impact military service members and veterans.