Project Grant HT94252310349

This $1,399,500 Project Grant award from the National Institutes of Health's Trans-NIH Research Support program (CFDA 93.310) will fund research at the University of Wisconsin - Madison to develop "cellular radio" circuits that can be used to visualize, probe, and perturb the dynamic protein activity in individual cells. The project aims to create genetically-engineered circuits that generate a frequency-modulated, barcoded fluorescent signal to track how the internal state of cells...

This federal Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), will support research to elucidate the role of TGF-beta signaling in craniofacial fibrous dysplasia (CFD) of the bone. The $306,600 award, effective from September 24, 2024 to September 23, 2026, will fund two key aims: 1) investigating the mechanisms driving TGF-beta signaling in response to G-protein coupled receptor...

This federal Project Grant award from the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), provides $534,899 to Baylor College of Medicine to define the cellular and molecular mechanisms governing neural crest cell development. The research aims to establish the syndrome Combined Methylmalonic Acidemia and Homocystinuria, cblC-type (CBLC) as a neurocristopathy, an inborn error of cobalamin...

This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program, provides $190,485.00 to support a 5-year research project investigating the molecular mechanisms underlying differentiation failure in neuroepithelial stem cells with NF2 mutations. The goal is to identify the cellular origins of spinal ependymoma tumors in patients with NF2...

This Project Grant award from the National Center for Advancing Translational Sciences (CFDA 93.350) provides $178,000.00 to Boston Children's Hospital to develop a bone marrow organoid system to study the rare genetic disorder RUNX1-Familial Platelet Disorder with Associated Myeloid Malignancy (RUNX1-FPD/MM). The 1-year project aims to generate bone marrow organoids from patient-derived induced pluripotent stem cell lines, both with and without the RUNX1 genetic mutation, to recapitulate the...

The National Institute of Biomedical Imaging and Bioengineering (NIBIB) awarded a $1,582,671 Project Grant under the "Discovery and Applied Research for Technological Innovations to Improve Human Health" (CFDA 93.286) program to the University of Connecticut (UConn) to develop a novel "bionic bone composite scaffold" (BBCS) for regenerating large bone defects without the use of stem cells, growth factors, or other biologics. The BBCS is designed to be a fully biodegradable,...

The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) awarded a $306,324 Project Grant (CFDA 93.846 - Arthritis, Musculoskeletal and Skin Diseases Research) to the Oklahoma Medical Research Foundation (OMRF) for a research project titled "Deciphering the Myofibroblast Life Cycle in Skin Wound Healing". The project aims to create a molecular map of the myofibroblast life cycle and investigate the role of Hippo-YAP/TAZ signaling in myofibroblast deactivation...

This Project Grant award, valued at $159,512.00, was provided by the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research federal grant program (CFDA 93.837). The funding supports research to uncover effective strategies for mitigating the detrimental effects of cardiac fibrosis, a prominent hallmark of dilated cardiomyopathy (DCM), an inherited heart disease. The key products and services to be delivered include: 1) validating and describing the...

This Project Grant award from the National Institute of Biomedical Imaging and Bioengineering (NIBIB), under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286), aims to develop a point-of-care instrument for rapid, non-destructive assessment of bone marrow aspiration sample adequacy. The $1,074,143 award to Cellia Science, Inc. will fund the transition of a deep-ultraviolet microscopy technology to a commercial-grade device. This...

This $877,001 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program supports a research initiative aimed at elucidating the cellular and molecular mechanisms underlying the clinical heterogeneity observed in Neurofibromatosis Type 1 (NF1). Specifically, the project will leverage patient-derived induced pluripotent stem cells, primary...