This Project Grant award from the Department of Defense's Military Medical Research and Development program (CFDA 12.420) provides $1,746,347 to Cedars-Sinai Medical Center to conduct research on "INTERROGATING TUMOR-IMMUNE-NEURON CROSS TALK AT SINGLE-CELL RESOLUTION IN A PANEL OF NOVEL SOMATIC TRANSGENIC NF1 TUMOR MODELS". The primary objective is to develop and validate new mouse models of neurofibromatosis type 1 (NF1) low- and high-grade gliomas, and to determine the role of neurons in their formation and growth. A sub-award of $414,438 was provided to The Washington University to support this research project.