This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $676,000.00 to the Icahn School of Medicine at Mount Sinai to study the impact of the 2016 CDC opioid prescribing guidelines on opioid utilization disparities among older adults with opioid-responsive pain conditions. The research will focus on three vulnerable subgroups of older adults: those with Alzheimer's and related dementias, racial/ethnic minorities, and those experiencing...
This federal Project Grant award from the Substance Abuse and Mental Health Services Administration (SAMHSA) under the Substance Abuse and Mental Health Services Projects of Regional and National Significance program (CFDA 93.243) provides $2,499,815 to the University Hospitals Cleveland Medical Center (UHCMC) to decrease opioid usage in the emergency department (ED) by increasing provider knowledge and implementing alternative to opioid (ALTO) therapies such as acupuncture and music-assisted...
This $701,959 Project Grant awarded by the National Institute on Drug Abuse (CFDA 93.279 Drug Use and Addiction Research Programs) aims to improve perioperative care for patients with opioid tolerance undergoing common surgical procedures. The key objectives are to: Capture patient-reported opioid use and pain outcomes among opioid-tolerant individuals after surgery and develop guidelines for appropriate opioid prescribing in this population. Conduct qualitative interviews to inform the...
This Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), provides $598,312 to Addinex Technologies, Inc. to integrate and assess the practicality of a closed-loop medication management system for opioid pain management in ambulatory patients with extremity fractures being discharged from the emergency department. The key objectives are to: 1) Adapt the Addinex system to seamlessly integrate with hospital pharmacy...
This $779,969 Project Grant awarded by the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279) aims to improve perioperative care for patients with opioid use disorder. The grant will fund a 5-year study to prospectively capture patient-reported pain and opioid use among individuals with opioid use disorder undergoing common surgical procedures, and develop a clinical care pathway to optimize perioperative outcomes across a network of...
This Project Grant award, funded by the Substance Abuse and Mental Health Services Administration (SAMHSA) under the Substance Abuse and Mental Health Services Projects of Regional and National Significance program (CFDA 93.243), will enable Kettering Medical Center Network to implement the PAUSE Pathway for Opioid Alternatives in the Emergency Department in a Western Ohio hospital system. The $1,397,454 award will be used to: 1) Revitalize and update the PAUSE "Alternatives to...
This $1,985,038 Project Grant award from the Substance Abuse and Mental Health Services Administration (SAMHSA) under the Substance Abuse and Mental Health Services Projects of Regional and National Significance (CFDA 93.243) program will implement a community-based screening, intervention, and linkage to substance use and mental health services program in the Mott Haven neighborhood of New York City. The project has two key components: 1) Community SBIRT (Screening, Brief Intervention, and...
This Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), provides $708,397 to investigate the role of inflammasomes in opioid-induced hyperalgesia (OIH) in the context of HIV-associated pain. The key objectives are to: 1) construct a cell atlas of opioid-targeted inflammasomes in the spinal cord of HIV pain models, 2) elucidate the role of Wnt5a signaling in establishing inflammasome cell maps, and 3) determine...
This federal Project Grant award of $683,583 from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), will support research to estimate the potential impacts of four alternative methadone treatment (MT) policy scenarios in New York State. The project will use an agent-based computer simulation model to analyze how changes to MT access points, such as through OTPs, mobile units, prescribers, and pharmacies, could influence methadone...
The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $6,809,660 Cooperative Agreement under the Drug Use and Addiction Research Programs (CFDA 93.279) to the University of Pittsburgh to implement and personalize opioid-sparing pain management protocols for major pediatric surgeries. The project aims to investigate the efficacy and safety of a standardized methadone-based Enhanced Recovery After Surgery (ERAS) protocol, as well as develop personalized ERAS approaches...
This $1,500,000 Project Grant from the Substance Abuse and Mental Health Services Administration (SAMHSA) under the Substance Abuse and Mental Health Services Projects of Regional and National Significance program (CFDA 93.243) will enable the Icahn School of Medicine at Mount Sinai to adapt and implement opioid-sparing pain management protocols across the Mount Sinai Health System's eight emergency departments in New York City.
The project aims to create a systematic approach to delivering opioid-sparing pain management for patients presenting with five specific conditions: headache/migraine, musculoskeletal pain, renal colic, chronic abdominal pain, and extremity fracture/joint dislocation. This will involve adapting the Alternatives to Opioids (ALTO) pain management pathways, developing electronic health record order sets, training emergency department medical and nursing staff, and continuously monitoring and re-evaluating the resulting pain management protocols. The goal is to reduce opioid analgesia administered during and prescribed after emergency department visits for these targeted conditions.