Project Grant FM1HL185879

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This federal Project Grant award from the National Cancer Institute (CFDA 93.398 - Cancer Research Manpower) provides $147,486 to Yale University to elucidate the mechanisms underlying the progression of non-small cell lung cancer (NSCLC) to leptomeningeal disease (LMD). The primary objectives are to identify the pathophysiological mechanisms driving the progression to LMD, particularly in cases of EGFR-mutant NSCLC that become resistant to tyrosine kinase inhibitor (TKI) treatment. The research...

This Project Grant award from the National Heart Lung and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) provides $235,608 to the University of Texas Southwestern Medical Center to conduct research on the impact of defective lipoylation on cardiac function and failure. The research aims to characterize the underlying mechanisms of cardiometabolic disorders using an inborn error of metabolism condition caused by LIPT1 gene deficiency as a model system. Key objectives include...

This Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) provides $233,180 to the Trustees of Boston University to fund their MD/PhD program. The grant aims to recruit, train, and support 4 MD/PhD students per year to develop them into clinician-scientist leaders capable of using both clinical and research expertise to address healthcare challenges and improve human health. The program...

The National Heart Lung and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), awarded a $106,533 project grant to the Regents of the University of Minnesota to elucidate the molecular mechanisms by which the PARP2 enzyme regulates RNA:DNA hybrids (R-loops) in myelodysplastic syndrome (MDS) cells harboring splicing factor mutations. The project aims to expand on prior work identifying R-loops as a unifying mechanism of disease pathogenesis in MDS, and will...

The National Institute of General Medical Sciences (NIGMS) awarded a $4,548,513 Project Grant under CFDA 93.859, the Biomedical Research and Research Training program, to Washington University in St. Louis. The grant will provide in-depth pre-doctoral training that integrates clinical medicine and biomedical research to train the next generation of physician-scientists. Key components of the 5-year program include a pre-clinical medical school curriculum with a "MSTP thread"...

This $201,426 federal Project Grant awarded by the National Heart, Lung, and Blood Institute under the Cardiovascular Diseases Research program (CFDA 93.837) supports a 5-year training program in patient-oriented research in cardiovascular endocrinology at Brigham & Women's Hospital Inc. The program aims to address an impending manpower crisis in patient-oriented research by providing comprehensive, curriculum-based training and mentored research projects for motivated trainees committed...

This $153,117 federal Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) supports the development of the recipient's independent research career as an academic hematopathology physician-scientist. The key objectives are to study hematopoietic stem and progenitor cell (HSPC) crosstalk and transplantation, with the overarching goal of improving HSPC transplantation outcomes. The award period runs from August 1, 2025 to July 31,...

This federal Project Grant award of $462,119, granted on September 8, 2025, was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The award supports a research project led by The Leland Stanford Junior University (Stanford University) to develop a new live-cell imaging technology called "Transposon Accelerated Chromatin Kinetic Imaging Technology" (TRACK-IT). This technology aims to enable...

This Project Grant award, provided by the National Heart Lung and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research), supports research on the use of donor-derived cell-free DNA for risk stratification and post-treatment monitoring of lung transplant patients at risk of chronic lung allograft dysfunction. The award, totaling $248,999.00, will be provided to the University of Maryland, Baltimore to fund this 3-year research project from July 2025 to May 2028. The project aims to...