Project Grant F32MH144876
- The National Institute of Mental Health awarded The Trustees of Princeton University $777,124 on June 15, 2026, under the Mental Health Research Grants program (CFDA 93.242) to investigate the computational and neural mechanisms underlying context inference and prediction. The recipient will combine computational models and electrophysiology in non-human primates to examine how context is represented and learned in the brain. Research will focus on three theoretical mechanisms for learning...
- The National Institute of Mental Health awarded The Trustees of The University of Pennsylvania $762,440 on April 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to develop and validate a concurrent transcranial magnetic stimulation and functional MRI protocol for measuring the effects of continuous theta burst stimulation to the right dorsolateral prefrontal cortex on anxiety-related neural and behavioral responses. The protocol will assess TMS-evoked BOLD responses and...
- The National Institute of Mental Health awarded The Leland Stanford Junior University $426,991 under the Mental Health Research Grants program (CFDA 93.242) on August 3, 2026, to support research decoding medial prefrontal cortex (MPFC) plasticity across developmental life stages. The recipient is investigating critical periods of synaptic plasticity in the MPFC using high-throughput assays measuring long-term potentiation in mouse brain slices via multielectrode recording arrays. Aim 1 maps...
- The National Institute of Mental Health awarded New York University $435,974 on May 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to develop computational models that quantify individual differences in learning and decision-making and predict psychiatric symptoms. The award funds development of a novel computational framework combining recurrent neural networks and dynamical systems theory to model reward learning processes at the individual level rather than group...
- The National Institute of Mental Health awarded the University of Miami $731,258 on March 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to map neural dynamics linked to major depressive disorder and generalized anxiety disorder using high-stakes real-world events. The recipient will conduct fMRI neuroimaging across five sessions with 144 undergraduate participants—72 diagnosed with GAD or MDD and 72 controls—leveraging naturally occurring emotional events during...
- The National Institute of Mental Health awarded The Washington University $103,310 on August 3, 2026, under the Mental Health Research Grants program (CFDA 93.242, K99MH144521) to investigate the causal dynamics of human amygdala-prefrontal circuits during fear extinction learning. The recipient will conduct intracranial electrophysiology and neuromodulation research using clinically indicated stereoelectroencephalography electrodes implanted in epilepsy patients undergoing SEEG monitoring....
- The National Institute of Mental Health, part of the Department of Health and Human Services, awarded the University of California, San Diego $684,740 on September 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to investigate neurocognitive mechanisms underlying fear extinction learning and to test whether computer-based working memory training enhances exposure-based treatment for anxiety disorders. The research will examine whether working memory training administered...
- The National Institute of Mental Health awarded The McLean Hospital Corporation $179,096 on June 18, 2026, under the Mental Health Research Grants program (CFDA 93.242) to investigate neurocognitive mechanisms underlying negative retrieval bias in major depressive disorder. The recipient will conduct research to distinguish between two competing mechanisms that may explain how depression disrupts emotional memory: increased familiarity (depression strengthens evidence for all negative...
- The National Institute of Mental Health awarded New York University $855,442 on September 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to characterize neural signatures of anxiety risk in infancy through longitudinal investigation of the mismatch negativity response as a potential biomarker. The project, titled "Characterizing Neural Signatures of Anxiety Risk in Infancy," recruits 250 mother-infant dyads at high risk for anxiety (with half of mothers carrying...
- The National Institute of Mental Health awarded the University of Southern California $751,034 on August 6, 2026, under the Mental Health Research Grants program (CFDA 93.242) to support a neuroscience research project examining how the brain processes uncertainty in noisy, dynamically changing environments. The project, titled "Unraveling Neural Mechanisms Underlying Learning in a Noisy, Dynamically Changing World," investigates computational and neural mechanisms by which the brain...
The National Institute of Mental Health awarded The Trustees of Princeton University $152,600 under the Mental Health Research Grants program (CFDA 93.242) on November 1, 2026, to conduct neural decoding research on biases in latent cause inference during fear extinction in anxiety disorders. The research leverages computational frameworks and neural decoding from optically-pumped magnetoencephalography (OPM-MEG) in combination with physiological markers including skin conductance response and pupillometry to decode the contents of inferred cognitive states and identify neural fingerprints of distinct pathways to sustained fear following extinction learning. The project investigates whether persistent threat responses in anxiety disorders arise from overgeneralization of threat across contexts—specifically, whether individuals infer a single latent cause combining both safe and threatening cues that remains persistently linked to threat, as opposed to successfully extinguishing the threat association. Work is performed at Princeton, New Jersey, with a period of performance from November 1, 2026, through October 31, 2029. This is a project grant, a standard assistance type under the Mental Health Research Grants program supporting competitive research proposals evaluated on scientific and technical merit, program relevance, and program balance through peer review and the National Advisory Mental Health Council.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $76.3k | 4/29/26 | ||
| Not listed | $0 | 4/29/26 | ||
| Not listed | $76.3k | 4/29/26 |