Project Grant F32MH143397
- The National Institute of Mental Health awarded University of Massachusetts Medical School $460,625 on August 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to investigate neurexin genes' role in serotonin circuitry and social behavior deficits associated with autism spectrum disorder. The award is a Project Grant (R21MH144157) with performance period through July 31, 2028, and place of performance in Worcester, Massachusetts. The research elucidates molecular...
- The National Institute of Mental Health awarded the University of Massachusetts Medical School $125,169 on July 30, 2026, under the Mental Health Research Grants program (CFDA 93.242, assistance type: Project Grant) to investigate brain metabolic dysfunction as a mechanism underlying autism spectrum disorder. The project uses non-invasive magnetic resonance spectroscopy to measure brain metabolites as markers of metabolic dysfunction in autistic adolescents relative to non-autistic peers,...
- The National Institute of Mental Health awarded The Washington University $763,894 on June 19, 2026, under the Mental Health Research Grants program (CFDA 93.242) to investigate the role of the ZNF292 gene in cortical development and neurodevelopmental disorders. The research employs complementary experimental systems—mouse knockout models and human pluripotent stem cell-derived neurons carrying six pathogenic ZNF292 variants identified in patients with autism spectrum disorder, intellectual...
- The National Institute of Mental Health awarded Massachusetts General Hospital $824,728 on March 25, 2026, under the Mental Health Research Grants program (CFDA 93.242) to characterize intracortical feedforward and feedback sensory processes in autism spectrum disorder. The award funds a multimodal neuroimaging study examining the hypothesis that autism spectrum disorder involves a fundamental imbalance between bottom-up (feedforward) and top-down (feedback) information flow in sensory cortex....
- The National Institute of Mental Health awarded The Washington University $147,268 on February 15, 2026, under the Mental Health Research Grants program (CFDA 93.242) to investigate the function of autism spectrum disorder risk genes RFX3 and RFX4 during human cortical development. The research examines how pathogenic mutations in the genes encoding regulatory factor X3 and X4 transcription factors contribute to autism spectrum disorder and other neurodevelopmental disorders. The investigator...
- The National Institute of Mental Health awarded Massachusetts Institute of Technology $805,382 on September 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to study social perception and cognition in a marmoset model of Phelan-McDermid Syndrome. The award funds research into neural impairments in social perception and cognition caused by SHANK3 gene mutations, with investigation of whether gene therapy can correct those impairments. MIT will implant electrocorticography...
- The National Institute of Mental Health awarded Cold Spring Harbor Laboratory $528,000 on June 19, 2026, under the Mental Health Research Grants program (CFDA 93.242) to support developmental characterization of synapses between neurons and oligodendrocyte precursor cells. The funded research investigates structural, functional, and molecular properties of neuron-OPC synapses, a class of synaptic connections that remain poorly understood despite evidence that oligodendrocyte precursor cells...
- The National Institute of Mental Health awarded Yale University $464,244 on June 15, 2026, under the Mental Health Research Grants program (CFDA 93.242) to screen the functionality of PTEN variants and pharmacological candidates in vivo using zebrafish models. The research will establish genotype-phenotype correlations for human PTEN variants in developing vertebrate brains and identify novel pharmacological suppressors of PTEN-associated phenotypes relevant to autism spectrum disorders. The...
- The National Institute of Mental Health awarded Yale University $157,388 on July 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to functionally characterize somatic mosaic variants in the brains of patients with schizophrenia and autism and determine their causal roles in neurodevelopmental disease. The funded work applies massively parallel reporter assays, CRISPR technology, and human induced pluripotent stem cell-derived neural progenitor cells and post-mitotic neurons...
- The National Institute of Mental Health awarded the University of California, Los Angeles $772,569 on August 17, 2026, under the Mental Health Research Grants program (CFDA 93.242) to conduct highly parallel analysis of high-confidence autism spectrum disorder and schizophrenia risk gene mechanisms. The recipient will study approximately 50 risk genes identified as harboring rare, protein-disrupting heterozygous mutations associated with these neuropsychiatric disorders. The work leverages a...
The National Institute of Mental Health awarded the University of Massachusetts Medical School $162,560 on February 4, 2027, under the Mental Health Research Grants program (CFDA 93.242) to define molecular pathways in monoamine circuit development using autism-related syndrome genes in zebrafish. The recipient will conduct behavioral assays, sequencing, and imaging of monoamine circuits and brain-wide activity changes in zebrafish with mutations in genes associated with autism-related syndromes, including TCF4 (Pitt-Hopkins), ARID1B (Coffin-Siris), BCL11BA, TCF7L2, ASH1L, FOXP1B, and HIVEP2A. Work includes bulk RNA sequencing, CUT & RUN, single-cell combinatorial indexing sequencing, and manipulation of downstream direct targets to define changes in molecular pathways caused by these genes. The project will also define effects on brain activity during behavioral tasks, examining how these syndromic genes influence dopamine signaling critical for social behaviors, learning, and memory. The research aims to prioritize which genes warrant investigation in future autism-related gene research and help explain how intellectual disability and other autism spectrum symptoms emerge from monogenic conditions. Performance occurs in Worcester, Massachusetts. The project period runs from February 4, 2027, through August 19, 2029. This is a Project Grant, the standard assistance type under the Mental Health Research Grants program.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $0 | 8/6/26 | ||
| Not listed | $0 | 8/6/26 | ||
| Not listed | $81.3k | 8/6/26 |