Project Grant F32HL189191
- The National Heart, Lung, and Blood Institute (NHLBI) at the Department of Health and Human Services awarded The Leland Stanford Junior University $755,271 on August 25, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to develop, validate, and clinically evaluate a magnetic resonance imaging method for assessing blood flow hemodynamics in pediatric and young adult congenital heart disease patients. The project will augment 4D-flow MRI capabilities to enable direct...
- The National Heart, Lung, and Blood Institute awarded The Leland Stanford Junior University $767,249 on June 22, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to develop and validate computational models for designing organ-scale vasculature in biomanufactured cardiac tissues. The project addresses the need for patient-specific engineered tissues to repair complex congenital heart defects, particularly large ventricular septal defects where current surgical approaches...
- The National Heart, Lung, and Blood Institute awarded The Leland Stanford Junior University $105,476 for a Project Grant (CFDA 93.837, Cardiovascular Diseases Research) on January 25, 2027. The award funds research addressing two critical shortcomings in the current donor heart allocation system. The project develops data-driven policy solutions to improve the prioritization of candidates with durable left ventricular assist devices (LVADs), which extend time on mechanical support but are...
- The National Heart, Lung, and Blood Institute awarded the Research Institute At Nationwide Children's Hospital $3.147 million on July 1, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to develop surgical strategies improving long-term outcomes after Fontan surgery in children with single ventricle disease. The project addresses the long-term complications of the Fontan operation, a palliative surgical procedure that remains the standard of care for single ventricle...
- The National Heart, Lung, and Blood Institute awarded The Leland Stanford Junior University $163,160 on February 12, 2027, under the Cardiovascular Diseases Research program (CFDA 93.837) to characterize neoaortic valve biomechanics in the Ross procedure for congenital aortic valve disease. The research addresses durability limitations of the Ross procedure, in which a patient's healthy pulmonic valve is translocated to the aortic position. While the procedure offers a living valve replacement...
- The National Heart, Lung, and Blood Institute awarded The Leland Stanford Junior University $768,912 on July 15, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to identify and validate genetic variants associated with cardiac differentiation and congenital heart disease. The research integrates artificial intelligence with genome engineering to discover intrinsic gene regulatory networks governing heart development. Stanford will employ a base-resolution neural network...
- The National Institutes of Health National Heart, Lung, and Blood Institute awarded The Leland Stanford Junior University $737,415 on August 17, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to examine the association between hospital market competition and inappropriate vascular surgical care in older adults. The recipient will conduct a research study analyzing overtreatment patterns in two conditions: abdominal aortic aneurysm (AAA) repair at small sizes not supported...
- The National Heart, Lung, and Blood Institute awarded The Leland Stanford Junior University $162,391 on August 15, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to define mechanisms of cardiovascular dysfunction in Down syndrome and identify therapeutic candidates. The research uses vascularized cardiac organoids derived from human pluripotent stem cells, integrated with single-cell multi-omics, high-throughput screening, and artificial intelligence-driven data mining to...
- The National Heart, Lung, and Blood Institute awarded The Leland Stanford Junior University $770,000 on April 1, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to fund research unraveling endothelial-cardiomyocyte crosstalk in cardiomyopathy using an integrated multimodal approach. The research examines molecular mechanisms by which endothelial dysfunction contributes to cardiac dysfunction in cardiomyopathy, focusing on cell-to-cell signaling between endothelial cells...
- The National Heart, Lung, and Blood Institute awarded The Leland Stanford Junior University $516,181 on September 1, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to conduct a prospective observational ancillary study nested within the MIDAS (Milrinone for Prevention of Post-Ligation Cardiac Syndrome) clinical trial. The study uses non-invasive bedside monitoring techniques—near-infrared spectroscopy (NIRS), lung ultrasound (LUS), and targeted neonatal echocardiography...
The National Heart, Lung, and Blood Institute (NHLBI) awarded The Leland Stanford Junior University $163,160 on February 10, 2027, under the Cardiovascular Diseases Research program (CFDA 93.837) to optimize Fontan creation and failing Fontan ventricular assist device (VAD) implementation using patient-specific computational flow modeling and ex-vivo 4D-flow MRI cardiac simulation. The recipient will develop and validate patient-specific computational models testing hepatic flow distributions and energy loss between lateral tunnel and extracardiac Fontan surgical techniques using an ex-vivo cardiac simulator compatible with 4D-flow MRI. The work applies these findings to pre-operative planning for Fontan creation in single ventricle patients, investigating whether hepatic flow distribution predicts abnormal venous anatomy and arteriovenous malformation (AVM) formation. For failing Fontan patients, the research tests whether continuous or pulsatile VAD support in ventriculo-aortic or Fontan-pulmonary artery configurations improves hemodynamics to inform optimal VAD implementation strategy. The period of performance runs from February 10, 2027, through February 9, 2028. Work is performed in California. The assistance type is a Project Grant.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $0 | 8/21/26 | ||
| Not listed | $81.6k | 8/11/26 |