Project Grant K99HL188273
- The National Heart, Lung, and Blood Institute awarded The Leland Stanford Junior University $767,249 on June 22, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to develop and validate computational models for designing organ-scale vasculature in biomanufactured cardiac tissues. The project addresses the need for patient-specific engineered tissues to repair complex congenital heart defects, particularly large ventricular septal defects where current surgical approaches...
- The National Heart, Lung, and Blood Institute awarded J. David Gladstone Institutes $131,307 on July 21, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to support a K99/R00 career development project investigating chromatin and spatial mechanisms underlying congenital heart defects in Down syndrome. The research, led by Dr. Feiya Li, dissects how increased dosage of the HMGN1 gene on chromosome 21 alters chromatin structure, gene regulation, and spatial cell signaling...
- The National Heart, Lung, and Blood Institute awarded The Leland Stanford Junior University $768,912 on July 15, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to identify and validate genetic variants associated with cardiac differentiation and congenital heart disease. The research integrates artificial intelligence with genome engineering to discover intrinsic gene regulatory networks governing heart development. Stanford will employ a base-resolution neural network...
- The National Heart, Lung, and Blood Institute awarded The Leland Stanford Junior University $770,000 on April 1, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to fund research unraveling endothelial-cardiomyocyte crosstalk in cardiomyopathy using an integrated multimodal approach. The research examines molecular mechanisms by which endothelial dysfunction contributes to cardiac dysfunction in cardiomyopathy, focusing on cell-to-cell signaling between endothelial cells...
- The National Heart, Lung, and Blood Institute awarded The Leland Stanford Junior University $1,541,206 on July 15, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to identify druggable targets for cancer therapy-induced cardiotoxicity. The research characterizes proteasome inhibitor-induced cardiovascular toxicity through three aims. Aim 1 profiles cell type-specific cytotoxicity using patient-specific induced pluripotent stem cell-derived cardiomyocytes and endothelial...
- The National Heart, Lung, and Blood Institute awarded The Leland Stanford Junior University $768,830 on July 6, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to investigate immune-fibroblast crosstalk in genetic dilated cardiomyopathy. The research integrates patient-specific induced pluripotent stem cells (iPSCs), three-dimensional cardiac organoids embedded in engineered disease-specific niches, CRISPR-based high-throughput screening, single-cell RNA sequencing,...
- The National Heart, Lung, and Blood Institute awarded The Leland Stanford Junior University $509,334 on August 15, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to develop a high-throughput software package and associated protocols that measure diastolic mechanics in cardiomyocytes using optical microscopy. The project addresses a critical gap in heart failure with preserved ejection fraction (HFpEF) drug discovery. Current tools measure contractile forces and systolic...
- The National Heart, Lung, and Blood Institute (NHLBI) at the Department of Health and Human Services awarded The Leland Stanford Junior University $755,271 on August 25, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to develop, validate, and clinically evaluate a magnetic resonance imaging method for assessing blood flow hemodynamics in pediatric and young adult congenital heart disease patients. The project will augment 4D-flow MRI capabilities to enable direct...
- The National Institutes of Health National Heart, Lung and Blood Institute awarded The Leland Stanford Junior University $165,887 on June 5, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to investigate multi-level drivers of pregnancy-related cardiovascular outcomes across the life-course. The award funds research to elucidate mechanisms by which community disinvestment across the life-course influences perinatal cardiometabolic dysfunction and short- and long-term...
- The National Heart, Lung, and Blood Institute awarded The Leland Stanford Junior University $769,846 on July 1, 2026, under Cardiovascular Diseases Research (CFDA 93.837), a Project Grant assistance type. The recipient will develop and apply an integrative genomics toolkit to characterize and engineer edits to regulatory DNA sequences with the goal of reprogramming gene expression for therapeutic applications. The toolkit combines computational models to predict how sequence changes to enhancers...
The National Heart, Lung, and Blood Institute awarded The Leland Stanford Junior University $162,391 on August 15, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to define mechanisms of cardiovascular dysfunction in Down syndrome and identify therapeutic candidates. The research uses vascularized cardiac organoids derived from human pluripotent stem cells, integrated with single-cell multi-omics, high-throughput screening, and artificial intelligence-driven data mining to investigate how trisomy 21 drives cardiovascular pathogenesis. Three specific aims structure the K99/R00 award: define T21-induced cardiovascular abnormalities in Down syndrome organoids using multi-omics; discover therapeutics through AI-driven data mining and screening; and validate promising compounds in vitro and in vivo. The project targets chronic interferon pathway hyperactivation as a driver of trisomy 21-induced abnormalities and aims to establish a versatile discovery platform with translational potential for drug development and precision medicine. Performance occurs in Palo Alto, California, with a period of performance through June 30, 2028. The award is classified as a Project Grant.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | ($162k) | 8/25/26 | ||
| Not listed | $162.4k | 8/14/26 |