Project Grant F32GM165117
- The National Institute of General Medical Sciences awarded Scripps Research Institute $506,000 on July 20, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to decode membrane protein folding and functional principles using designed building blocks. The research integrates protein design with biophysical experiments to clarify fundamental chemical rules and sequence-structure relationships governing how proteins interact in lipid membranes. Membrane proteins are...
- The National Institute of General Medical Sciences awarded Scripps Research Institute $506,000 on July 1, 2026, to conduct research deciphering the molecular principles linking PopZ filament structure to condensate function under the Biomedical Research and Research Training program (CFDA 93.859). The research integrates advanced methodologies including cryo-electron tomography, MINFLUX nanoscopy, single-molecule FRET, proteomics, and integrative modeling to study how filamentous biomolecular...
- The National Science Foundation Division of Chemistry awarded a $1,050,000 Project Grant to the Scripps Research Institute under the Mathematical and Physical Sciences federal grant program (CFDA 47.049) to support research exploring attached-ring cross-coupling chemistry and its applications. Over a three-year period from August 1, 2022 to July 31, 2025, Professor Ryan Shenvi of Scripps Research Institute will develop new non-precious metal reagents and methods for concise syntheses of...
- The National Institute of General Medical Sciences, a bureau of the National Institutes of Health within the Department of Health and Human Services, awarded $301,936 to the University of California, Los Angeles on March 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859). The award funds data-science-guided study and design of phosphoranyl radical-mediated reactions for the discovery of novel pharmaceutical compounds. The research builds a comprehensive,...
- The National Institute of General Medical Sciences awarded the Trustees of Indiana University $340,016 on August 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop innovative single-electron radical chemistry methods for medicinal synthesis. The funded research advances synthetic methods to build complex, three-dimensional small molecules containing fluorine and other functional groups that improve drug performance. Traditional cross-coupling...
- The National Science Foundation Division of Chemistry awarded a $662,000 Project Grant to the Scripps Research Institute from September 1, 2021 through August 31, 2026 under the Mathematical and Physical Sciences program (CFDA 47.049). The grant will support research activities focused on catalytic activation of alkenyl C-H bonds. As part of the Mathematical and Physical Sciences program's goal of strengthening the nation's scientific enterprise through advancing knowledge and understanding of...
- The National Institute of Biomedical Imaging and Bioengineering awarded Scripps Research Institute $276,000 on August 1, 2026, under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) to develop and validate novel fluorescence resonance energy transfer (FRET) sensing methods that leverage entangled photons for biomedical applications. The project will explore quantum sensing technologies to advance FRET-based detection across biological...
- The National Institute of General Medical Sciences awarded President and Fellows of Harvard College $226,404 on June 22, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop selective methods for N-alkylation of azoles via anion-binding catalysis. The research addresses a long-standing synthetic challenge in azole chemistry. Azoles appear in approximately one-third of commercial pharmaceuticals, but selective preparation of N-alkylated azoles currently...
- The National Institute of General Medical Sciences awarded $502,372 to Massachusetts Institute of Technology on July 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop selective, catalytic isomerization reactions that convert simple organic building blocks into complex organic molecules relevant to biomedical research. The work encompasses stereocenter editing—precise interconversion of stereoisomeric molecules at late synthetic stages to enable...
- The National Institute of General Medical Sciences awarded California Institute of Technology $446,219 on March 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to advance selective reactions of carbocations in synthetic chemistry. The funded research expands enantioselective C-H insertion reactions of catalytically generated vinyl carbocations to access diverse cyclic and polycyclic systems. The work develops innovative electrophilic reactions and...
The National Institute of General Medical Sciences awarded Scripps Research Institute $151,760 on November 25, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop single-electron pathways toward carbon-fluorine bond functionalization for pharmaceutical synthesis. The project designs fluorophilic radical reagents based on phosphorus, silicon, boron, and aluminum, activated via electrochemical redox to promote fluorine-atom abstraction from carbon-fluorine bonds. The resulting carbon-centered radicals will be harnessed for carbon-carbon and carbon-heteroatom bond formations. This approach addresses the challenge that existing carbon-fluorine bond functionalization methods rely on harsh two-electron polar pathways that limit functional group compatibility. Single-electron radical cross-coupling strategies would enable construction of gem-difluoro motifs and other valuable structures from widely available trifluoromethyl building blocks, supporting the broader pharmaceutical interest in carbon-fluorine bonds, which appear in approximately 20 percent of all pharmaceuticals. The award runs through August 2, 2029, with performance at Scripps Research Institute in La Jolla, California.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $75.9k | 5/26/26 | ||
| Not listed | $75.9k | 5/26/26 | ||
| Not listed | $0 | 5/26/26 |