Project Grant F32GM159381
- The National Institute of General Medical Sciences awarded the University of Cincinnati $760,178 on September 10, 2025, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate molecular mechanisms that determine circadian rhythm period and light-dependent phase shift. The recipient will combine mathematical modeling, statistical uncertainty quantification methods, and experimental validation to elucidate how transcriptional and translational feedback loops...
- The National Institute of General Medical Sciences awarded Vanderbilt University $648,480 on June 12, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to support research on the mechanism and evolution of circadian clocks and photoperiodism. The award funds basic research examining post-translational molecular mechanisms of circadian clocks in bacterial and mammalian model systems. Work will address how biochemical mechanisms sustain long-period (~24 hour)...
- The National Institute of General Medical Sciences awarded California Institute of Technology $1.872 million on March 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to conduct research on mechanisms in the mammalian circadian clock. The research addresses gaps in understanding the central transcription-translation feedback loop (TTFL) that drives circadian oscillations, which regulate sleep-wake patterns, metabolism, and immune responses. The work comprises...
- The National Institute of General Medical Sciences awarded the University of California Santa Cruz $425,804 under the Biomedical Research and Research Training program (CFDA 93.859) on September 1, 2026, to establish eyed cnidarians (jellyfish) as model systems for investigating the cellular and molecular mechanisms of eye development and regeneration. The research will employ single-cell sequencing, in situ hybridization, and gene knockdowns to identify the cell types, cell trajectories, and...
- The Department of Health and Human Services National Institutes of Health Office of the Director awarded the University of California, Santa Barbara $430,375 on August 1, 2026, under the Research Infrastructure Programs (CFDA 93.351) to fund basic research on reversible stem cell dormancy in the basal chordate Botrylloides diegensis. The award supports investigation of mechanisms controlling stem cell dormancy and re-activation, using B. diegensis as a model organism. This species undergoes...
- The National Institute of General Medical Sciences awarded The Trustees of The University of Pennsylvania $487,287 on March 10, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to support investigation of circadian rhythm mechanisms beyond traditional genetic control. The research explores how cells and organisms maintain daily temporal organization through integration of genetic and non-genetic mechanisms, with focus on metabolic and redox processes that sustain...
- The National Institute of General Medical Sciences, part of the National Institutes of Health, awarded the University of California, Davis $393,008 on March 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to support research on the regulation of cell fate specification during the regeneration of complex sensory organs. The funded research uses the freshwater apple snail (Pomacea canaliculata) as a model organism to uncover molecular mechanisms driving...
- The National Institute of Child Health and Human Development awarded The Marine Biological Laboratory $431,112 on September 1, 2026, under the Child Health and Human Development Extramular Research program (CFDA 93.865) to investigate the role of neuropeptides in appendage regeneration. The research seeks to understand why salamanders and axolotls regenerate lost limbs, jaws, tails, and other tissues while humans retain only limited regenerative capacity. The work addresses therapeutic...
- The National Institute of Neurological Disorders and Stroke awarded the University of Massachusetts Medical School $460,625 on August 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to investigate time-dependent membrane proteomics in circadian pacemaker neurons. The recipient will use cutting-edge proteomic approaches combined with biotin proximity labeling to survey the membrane proteome of circadian neurons during the...
- The National Science Foundation Division of Molecular and Cellular Biosciences awarded the University of Massachusetts Medical School $1.261 million on August 1, 2026, under the Biological Sciences program (CFDA 47.074) to conduct collaborative research on the molecular and neural mechanisms controlling circatidal rhythms in the crustacean Parhyale hawaiensis. The research identifies genes that encode the circatidal clock—an internal ~12.4-hour biological timekeeper that enables marine animals...
The National Institute of General Medical Sciences, part of the Department of Health and Human Services, awarded $153,560 to the University of California, Santa Barbara on November 21, 2026, under the Biomedical Research and Research Training program (CFDA 93.859, Assistance Listing). The recipient will conduct physiological, molecular, and bioinformatic experiments to determine the role of circadian rhythms in modulating wound healing and whole-body regeneration, with focus on identifying the temporal windows of regeneration most susceptible to circadian control and the cellular mechanisms mediating these effects. The research tests the hypothesis that circadian clocks affect regeneration efficiency by controlling cell proliferation using the sea anemone Nematostella vectensis as an invertebrate model system. Work includes a series of circadian manipulations such as genetic clock defects and different environmental regimes, along with assays of morphological endpoints to determine effects of circadian rhythms on the temporal progression of whole-body regeneration and effects on cell proliferation. Performance occurs in Santa Barbara, California, with a period of performance extending from November 21, 2026, through May 20, 2029.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $0 | 5/21/26 | ||
| Not listed | $76.8k | 5/21/26 | ||
| Not listed | $76.8k | 5/21/26 |