Project Grant F32DK148145
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded Scripps Research Institute $142,600 on September 30, 2025, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to leverage in vivo protein tracking to identify novel immune markers associated with obesity-driven disease. The research develops and employs a Cre-inducible endogenous biotin-ligase BirA*G3 affinity tracking system expressed in mouse intestine to biotin-tag proteins...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded Scripps Research Institute $701,896 on September 1, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to investigate novel genetic pathways underlying brain-gut communication in C. elegans as a model for understanding systemic fat metabolism and metabolic dysfunction. The research systematically identifies and characterizes ciliated sensory neurons and the neuropeptide...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded Yale University $249,999 on July 1, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to investigate transcriptional dysregulation mechanisms in SF3B1-mutant myelodysplastic syndromes. The research focuses on defining the role of HTATSF1, a protein involved in both splicing and transcription, in transcriptional dysregulation in splicing-factor-mutant myelodysplastic...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded Sanford Burnham Prebys Medical Discovery Institute $910,940 on August 10, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to investigate post-transcriptional regulation of liver fibrosis by RNA binding proteins. The recipient will conduct basic research to identify and characterize RNA binding proteins (RBPs) that control fibrosis-related gene expression in liver cells,...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded The University of Texas Southwestern Medical Center $694,250 on March 1, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to explore a novel pathway for ApoB mRNA degradation in regulating VLDL secretion and steatotic liver disease. The recipient will conduct basic biomedical research identifying mechanisms by which the HELZ2 gene regulates hepatic lipid secretion...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded Baylor College of Medicine $200,000 on September 15, 2025, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847, assistance type Project Grant). The funded research investigates how proteostatic stress—arising from fever-range hyperthermia, altered oxygen tension, and modulation of protein quality control pathways including chaperones, proteasome activity, autophagy, and...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded the University of California, San Diego $795,197 on July 1, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) for Project Grant R01DK144618. The award funds research into nuclear cell biology and epigenetic mechanisms governing ligand-activated enhancers in the endocrine system. The project investigates how terminally oxidized DNA methylation marks—5-formylcytosine and...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded $178,000 to Beckman Research Institute of the City of Hope on May 1, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to conduct three-dimensional spatial and translational profiling of stress response pathways in Type 1 Diabetes. The research examines how proinflammatory cytokines activate the integrated stress response in pancreatic beta cells during early Type 1...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded the University of California, Los Angeles $128,235 on September 13, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The award funds research to discover mechanisms of metabolic dysfunction-associated steatotic liver disease (MASLD) through single nucleus RNA-sequencing analysis of cell-type and cellular subtypes in subcutaneous adipose tissue, visceral adipose...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded the University of California, Berkeley $632,201 on August 1, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to investigate the mechanisms governing lipid uptake, storage, and secretion in hepatocytes. The research addresses dysregulation of hepatic lipid processes underlying obesity-related steatosis and metabolic dysfunction-associated fatty liver disease. The work...
The National Institute of Diabetes and Digestive and Kidney Diseases awarded the Scripps Research Institute $152,600 on February 15, 2027, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The award funds research examining how hepatic endoplasmic reticulum (ER) stress affects the integrity of the secreted proteome, with focus on protein aggregation diseases including systemic amyloidoses. The research will use established and novel proteomics approaches to understand the molecular basis for ER stress-dependent secretion of disease-associated proteins in non-native conformations and the broader impact of ER stress on the global secretory proteome. The work will test the hypothesis that hepatic ER stress causes a fundamental breakdown in quality control pathways, broadly increasing secretion of proteins in non-native conformations that contribute to the pathogenesis of etiologically-diverse diseases linked to ER stress in the liver. Performance occurs at the Scripps Research Institute in La Jolla, California. The period of performance runs through December 31, 2028.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $76.3k | 6/26/26 | ||
| Not listed | $0 | 6/26/26 | ||
| Not listed | $76.3k | 6/26/26 |