This federal Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), provides $148,568 to investigate the mechanisms of dopamine transmission and its role in reward-related behaviors. The award period runs from January 1, 2025 to July 31, 2027. The funded research aims to advance the mechanistic understanding of how dopamine signaling occurs at the subcellular level, given limitations in prior methodologies. The...
This Project Grant award, with a total funding amount of $154,091, was provided by the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279). The grant supports research at Georgetown University to investigate the role of chloride homeostasis and inhibitory network activity in the ventral tegmental area of the brain during reward learning. Specifically, the project aims to characterize the expression of the anion transporter KCC2 and its...
This Project Grant award from the National Institute on Drug Abuse (NIDA), under the federal Drug Use and Addiction Research Programs (CFDA 93.279), provides $242,310 to The Medical College of Wisconsin, Inc. to investigate the role of GQ signaling in mobilizing the endocannabinoid 2-arachidonoylglycerol (2-AG) by corticosterone in the prefrontal cortex. The research aims to enhance understanding of the mechanism by which corticosterone regulates endocannabinoid signaling and its impact on...
This $145,642 federal Project Grant award was issued by the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279) to Northwestern University. The funding supports research to investigate the molecular mechanisms behind how the cannabinoid 2 receptor (CB2R) can recruit the arrestin signaling protein independently of G protein-coupled receptor kinases (GRKs). This research aims to simplify the study of arrestin-receptor interactions using...
This Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), provides $772,800 to the University of Florida to conduct research on pharmacologically targeting novel modulators of opioid signaling. The overarching goal is to dissociate the behavioral effects associated with opioid receptor activation to curb the development of dependence and tolerance. The research will involve using high-throughput screening...
This Project Grant award from the National Institute on Drug Abuse (NIDA), under the federal Drug Use and Addiction Research Programs (CFDA 93.279), provides $174,029.99 to the University of California, Irvine to investigate the role of the GILZ gene in regulating cocaine-induced cellular activity and cocaine-associated memory formation. The research aims to test the hypothesis that the GILZ gene, located on the X chromosome, acts in the nucleus accumbens to regulate transcription underlying...
This Project Grant award from the National Institute on Drug Abuse (NIDA), under the federal Drug Use and Addiction Research Programs (CFDA 93.279), provides $1,999,707 in funding to the University of Florida to conduct research on the role of the cell-adhesion molecule ELFN1 in regulating glutamatergic signaling and synaptic plasticity within the reward circuit of the brain. The goal is to understand how opioids alter these processes and contribute to addiction. The research plan involves a...
This Project Grant award from the National Institute on Drug Abuse (NIDA), under the federal Drug Use and Addiction Research Programs (CFDA 93.279), provides $373,300 to The Regents of the University of California, San Francisco (UCSF) to conduct research on the nucleus accumbens dynamics underlying cue-reward learning. The project aims to investigate how the brain selectively discriminates and responds to reward-predictive cues versus irrelevant ones, with a focus on the role of neuronal...
The National Institute on Drug Abuse (NIDA), part of the National Institutes of Health (NIH), awarded a $267,310 Project Grant under the Drug Use and Addiction Research Programs (CFDA 93.279) to the Regents of the University of Minnesota. The award will fund research to investigate the role of the neuropeptide VGF and its derived peptide TLQP-62 in facilitating synaptic plasticity in the nucleus accumbens and their contribution to opioid withdrawal behaviors. Key research activities include...
This $147,656 Project Grant was awarded by the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279). The grant will fund research at Emory University from February 1, 2025 through August 31, 2027 to examine the "modulatory role of galanin in opioid reward." Galanin is a neuropeptide that may play a key role in regulating the rewarding effects of opioids. This basic and clinical neuroscience research aims to develop new knowledge and...