Project Grant F32CA306485
Award Date 1/16/26
Completion Date 8/31/28
Dollars Obligated $150K
Federal Agency
Awardee
Federal Grant Program
Assistance Type
Project Grant
Place of Performance
Connecticut, USA
Similar Awards
- This Project Grant award from the National Cancer Institute (CFDA 93.393 - Cancer Cause and Prevention Research) supports research to define key components of the PRMT5 axis that impair cell viability upon PRMT5 inhibition and identify pathways that can restore viability in MTAP-deleted cancer cells. The $442,089 award to Yale University will leverage a genome-scale CRISPR activation platform to identify genes that modulate sensitivity to PRMT5 pathway inhibition. The research aims to...
- This Cooperative Agreement award from the National Cancer Institute (CFDA 93.396 - Cancer Biology Research) provides $953,922.00 in funding to the Scripps Research Institute in California to conduct research on the links between RNA modifications, codon use, translation, and metabolism in cancer cells. The overall goal is to identify correlations between modification states of the translation apparatus and changes in codon occupancy and translation rate across cancer cell lines, particularly...
- This Cooperative Agreement award of $922,755.00 from the National Cancer Institute under the Cancer Biology Research program (CFDA 93.396) supports research at the University of Massachusetts Medical School (UMASS Medical) aimed at understanding the role of tRNA modification and translational remodeling in cancer progression and metastasis. The project will use advanced RNA mass spectrometry, sequencing, and ribosome profiling techniques to comprehensively catalog tRNA modification dynamics...
- This federal Project Grant award of $194,914 from the National Cancer Institute (CFDA 93.398 - Cancer Research Manpower) supports research to investigate the role of trans-acting factors and cis-element sequences in activating oncogenes in rearranged human genomes. The awardee, the University of Texas Health Science Center at Houston, will employ CRISPR/Cas9 genome engineering to introduce chromosomal translocations near oncogenes and model their expression using single-cell multi-omic...
- This federal Project Grant award of $418,176 from the National Cancer Institute (CFDA 93.396 - Cancer Biology Research) supports the development and validation of a novel approach called "Programmable Nucleic Acid Cytometry" at the Sloan-Kettering Institute for Cancer Research. The project aims to advance this innovative method for profiling rare cell populations from tumors and tissues, which offers advantages over traditional antibody-based cell isolation techniques. The work will...
- This federal Project Grant award from the National Cancer Institute (CFDA 93.396 - Cancer Biology Research) provides $415,259 to the Rector & Visitors of the University of Virginia to conduct research on the role of long noncoding RNAs in acute myeloid leukemia (AML). The project aims to 1) determine the role of a specific regulatory RNA in primary and relapsed AML, and 2) define the mechanism underlying its deregulation in AML. This research will provide insights into how noncoding RNAs...
- This federal Project Grant award from the National Cancer Institute (CFDA 93.398 - Cancer Research Manpower) provides $147,486 to Yale University to elucidate the mechanisms underlying the progression of non-small cell lung cancer (NSCLC) to leptomeningeal disease (LMD). The primary objectives are to identify the pathophysiological mechanisms driving the progression to LMD, particularly in cases of EGFR-mutant NSCLC that become resistant to tyrosine kinase inhibitor (TKI) treatment. The research...
- This $147,486 federal Project Grant award from the National Cancer Institute's Cancer Research Manpower program (CFDA 93.398) supports research to characterize and define the role of glycosylated RNAs (glycoRNAs) in acute myeloid leukemia (AML) at Yale University. The research aims to 1) characterize glycoRNA expression and sequences in different AML subtypes compared to normal myeloid progenitors, 2) define the role of SIDT proteins in AML glycoRNA expression, and 3) determine the functions...
- This $380,337 federal Project Grant was awarded by the National Cancer Institute (NCI), under the Cancer Biology Research program (CFDA 93.396), to the University of Washington on March 1, 2025. The grant supports research to develop improved algorithms for optimizing mRNA sequences to enhance the expression and tissue targeting of mRNA cancer therapies. The project aims to combine machine learning and massively parallel reporter assays to build predictive models relating mRNA sequence to...
- This $150,104 Project Grant award from the National Cancer Institute's Cancer Research Manpower program (CFDA 93.398) supports research to understand the evolutionary trajectories of complex genomic rearrangements in cancer. The project aims to develop novel computational approaches, "AGAVE" and "ROSE", to characterize the timing and dynamics of focal amplifications and structural variants during tumor evolution. The research will map these evolutionary patterns across...