The National Cancer Institute (NCI) awarded a $179,988 Project Grant under the Cancer Biology Research (CFDA 93.396) program to The Leland Stanford Junior University (Stanford University) for the project "Modulating Human Microbiome Function to Enhance Immune Responses Against Cancer." The goal is to identify bacterial functions that can enhance response to immune checkpoint blockade (ICB) cancer immunotherapy. The project will leverage metagenomic data analysis, genetic engineering of...
The National Cancer Institute (NCI) awarded Carnegie Mellon University a $632,300 Project Grant under the Cancer Biology Research program (CFDA 93.396) to develop an integrated ultrahigh-throughput 3D volumetric super-resolution imaging system. This system will combine a multiscale fluorescence mesoscope with expansion microscopy to enable rapid, large-area 3D imaging at exceptional subcellular detail. The project aims to advance spatial biology in cancer research by visualizing interactions...
This $639,780 Cooperative Agreement award from the National Cancer Institute (CFDA 93.394 - Cancer Detection and Diagnosis Research) aims to characterize the early-stage colorectal cancer cell-free DNA (cfDNA) methylome landscape and develop a machine learning model for early detection of colorectal cancer. The awardee, The Leland Stanford Junior University, will generate cfDNA methylomes from patient samples to derive biomarker signatures, as well as build a classification model to detect...
This federal Project Grant award of $509,448.00 from the National Cancer Institute (CFDA 93.398 - Cancer Research Manpower program) supports research to investigate the role of antigen-presenting cells in modulating tumor-specific immune tolerance and metastatic progression. The primary objectives are to: 1) identify the specific antigen-presenting cell populations responsible for promoting tumor-specific regulatory T cell development in lymph nodes, and 2) assess therapeutic strategies to...
This federal Project Grant award for $166,428 from the National Cancer Institute's Cancer Research Manpower program (CFDA 93.398) will support a new T32 predoctoral training program at Stanford University to prepare the next generation of multi-disciplinary cancer researchers. The program, titled "Genetic and Environmental Basis of Cancer Risk and Disparities (GECARD)," will provide integrative training across fields like epidemiology, biostatistics, genetics, environmental health, and...
This $284,201.82 Project Grant from the National Cancer Institute, a division of the Department of Health and Human Services, will fund research into malignant cell engagement in immune circuits of human colorectal cancer. The Broad Institute, Inc. will utilize single cell RNA sequencing data from over 700,000 malignant, immune, and stromal cells from colorectal cancer patients to test the hypothesis that malignant cells expressing interferon-stimulated genes acutely promote anti-tumor immunity,...
The National Cancer Institute (NCI) awarded a $256,487 Project Grant under the Cancer Research Manpower (CFDA 93.398) program to the Sloan-Kettering Institute for Cancer Research in New York, NY. The purpose of this 5-year grant is to develop multimodal predictive models that integrate real-world data from circulating tumor DNA (ctDNA) sequencing, radiomics, tumor registries, and tissue genomics to improve risk stratification and clinical management of non-small cell lung cancer (NSCLC). The...
The National Cancer Institute awarded a $342,397 Project Grant (CFDA 93.398 - Cancer Research Manpower) to Wayne State University to investigate the relationship between MAIT cells and the microbiome in pancreatic cancer liver metastasis. The project aims to advance understanding of this connection and its potential impact on pancreatic cancer progression. The award period runs from September 30, 2024 to April 28, 2028, and the research will be conducted at Wayne State University in Detroit,...
This $1,592,358 federal Project Grant awarded by the National Cancer Institute (CFDA 93.396 - Cancer Biology Research) supports research at The Leland Stanford Junior University to investigate novel approaches for inducing cell death in small cell lung cancer (SCLC). The key objectives are to: 1) Determine how distinct SCLC cell states dictate apoptotic versus ferroptotic cell death pathways in response to cystine/cysteine (Cys) deprivation; 2) Understand how the Notch and NRF2 signaling...
This federal Project Grant award, provided by the National Cancer Institute's Cancer Research Manpower program (CFDA 93.398), supports research at The Leland Stanford Junior University (Stanford University) to develop novel pharmacological approaches that can rewire oncogenic gene expression and induce cancer cell death. The $135,594 award, effective from April 1, 2025 to March 31, 2027, aims to achieve two key objectives: 1) Develop small molecule chemical inducers of proximity (CIPs) that...