Project Grant F32AI200118
- The National Institute of Allergy and Infectious Diseases awarded the Regents of the University of Michigan $186,758 on February 9, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to conduct research on infection-induced cell cycle diversion and macrophage inflammatory biogenesis. The award funds investigation into how bacterial infection of macrophages, specifically by methicillin-resistant Staphylococcus aureus (MRSA), triggers structural and biochemical...
- The National Institute of Allergy and Infectious Diseases awarded the Regents of the University of Michigan $2.284 million on August 1, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to conduct research on microbial interactions combating antibiotic-resistant bacteria (MI-CARB). The research employs a systems biology approach to understand pathogenesis of nosocomial infections caused by three pathogen groups: vancomycin-resistant enterococci (VRE),...
- The National Institute of Allergy and Infectious Diseases awarded the Regents of the University of Michigan $329,539 on July 24, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to support the Transdisciplinary Training in RNA and Infection (TRAIN) program. TRAIN integrates 32 preceptors from 14 departments across 5 schools and institutes at the University of Michigan to mentor six graduate students in RNA biology, infectious disease research, and drug...
- The National Institute of Allergy and Infectious Diseases, part of the Department of Health and Human Services, awarded $571,412 to the University of Maryland, College Park on June 11, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855). The award funds research into the regulation of bacterial physiology and infections through linear diribonucleotides and RNA degradation. The project will characterize how diribonucleases and triribonucleases bind their respective...
- The National Institute of Allergy and Infectious Diseases awarded The Regents of the University of California, San Francisco $150,104 on January 12, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to explore leaderless mRNA translation in mycobacteria as a potential drug target for tuberculosis treatment. The research comprises three aims investigating how mycobacterial ribosomes translate leaderless mRNAs—transcripts lacking the 5' untranslated region and...
- The National Institute of Allergy and Infectious Diseases awarded Ferris State University $132,000 on September 2, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to develop a metabolic engineering platform for macrolide combinatorial biosynthesis. The funded research addresses antimicrobial resistance by designing and constructing novel biosynthetic pathways that produce new macrolide derivatives with altered hydroxylation and glycosylation patterns. The work...
- The National Institute of Allergy and Infectious Diseases awarded Northwestern University $549,246 on August 1, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to fund Project Grant R01AI192692, which investigates substrate selectivity and regulation of YHAM, a 3'-5' exonuclease in Methicillin-resistant Staphylococcus aureus (MRSA). The research examines how YHAM, an understudied bacterial enzyme required for MRSA virulence, functions through an unusual...
- The National Institute of Allergy and Infectious Diseases awarded the University of Illinois $236,407 on September 1, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate the structural basis of ARMA-mediated resistance to aminoglycoside antibiotics targeting the bacterial ribosome. The research addresses how ARMA methyltransferases confer high-level resistance to aminoglycosides—a cornerstone class of ribosome-binding antibacterial drugs used...
- The National Institute of Allergy and Infectious Diseases, a component of the Department of Health and Human Services, awarded the Regents of the University of Michigan $195,000 on September 1, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855, Project Grant R21AI201758). The recipient will develop a urea-inducible library of 217 transcription factors in Proteus mirabilis, a bacterium responsible for up to 44 percent of long-term catheter-associated urinary tract...
- The National Science Foundation Division of Molecular and Cellular Biosciences awarded the Regents of the University of Michigan $862,279 on June 1, 2026, to investigate RNA-RNA interactions that regulate virulence gene expression in Listeria monocytogenes, a foodborne pathogen of significant public health concern. The research will characterize how two noncoding RNAs in L. monocytogenes work together through an unconventional mechanism to control the expression of virulence genes—proteins...
The National Institute of Allergy and Infectious Diseases awarded $151,760 to the Regents of the University of Michigan on December 14, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to support postdoctoral research characterizing riboswitches in methicillin-resistant Staphylococcus aureus as potential antibiotic targets. The fellowship provides advanced, multidisciplinary training in RNA biology, structural biochemistry, and single-molecule fluorescence microscopy. The research investigates bacterial gene regulation by riboswitches—structured RNA elements that regulate gene expression by sensing cellular metabolites—to inform development of novel antibiotics. Riboswitches are ubiquitous in pathogens yet absent in humans, making them attractive antimicrobial targets. The work focuses on two functionally distinct MRSA riboswitches: the FMN riboswitch, a translational repressor, and the MN2 riboswitch, a translational activator. The postdoctoral researcher will employ single-molecule fluorescence assays, cryo-electron microscopy, and computational modeling to elucidate how ligand binding modulates riboswitch-mediated gene regulation and how riboswitches regulate transcriptional and translational processes. The award period runs from December 14, 2026, through June 30, 2029, with performance at Ann Arbor, Michigan.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $0 | 6/16/26 | ||
| Not listed | $75.9k | 6/16/26 | ||
| Not listed | $75.9k | 6/16/26 |