Project Grant F32AI194727
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $489,500 Project Grant under the Allergy and Infectious Diseases Research Federal Grant Program (CFDA 93.855) to The Children's Hospital Corporation (Boston Children's Hospital) on August 1, 2025. The grant supports research to characterize key cell wall stress response mechanisms and regulators in the fungus Candida albicans, with the goal of identifying novel antifungal therapeutic targets and strategies to...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $265,650 Project Grant under the Allergy and Infectious Diseases Research Federal Grant Program (CFDA 93.855) to HMH Hospitals Corporation, doing business as Hackensack University Medical Center, to study the effects of antifungal drug treatment and immune dysfunction on the evolutionary dynamics of the gut-colonizing fungus Candida glabrata. This research aims to provide insights into the population dynamics and drug...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $300,616 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to Shy Therapeutics, LLC to develop a novel class of small molecule antifungal therapies. The project aims to identify and optimize new chemical compounds with potent activity against drug-resistant fungal strains, including Cryptococcus neoformans and Candida auris, through a structure-activity relationship (SAR) approach....
- This $807,498 Project Grant awarded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) supports research on the evolution of Cryptococcus neoformans strains in HIV/AIDS patients. The funded work aims to develop a comprehensive platform for characterizing the genotypes and phenotypes of over 3,000 global C. neoformans isolates, leveraging advanced genomic analysis and high-throughput phenotypic screening...
- This $6,977,446 Cooperative Agreement award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research Federal Grant Program (CFDA 93.855), will establish a Center of Excellence in Translational Research focused on rapid development of new drugs and diagnostics to combat invasive fungal infections caused by drug-resistant pathogens. Key projects include collaborations with industry partners to develop advanced small molecule drugs...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $245,250 Project Grant under the Allergy and Infectious Diseases Research (CFDA 93.855) program to The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center. The grant will fund the development of a novel mouse model to study the immunological consequences of neonatal colonization by the fungus Candida albicans, which is a common commensal on mucosal surfaces. The research aims to characterize...
- This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) provides $239,250 to Brown University to investigate the life-cycle transitions of trypanosomatid parasites, which cause severe diseases globally. The funding will support the use of a novel agarose microwell method to conduct live-cell imaging of trypanosomatid cellular processes, such as cell division, that have previously been difficult to...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $147,486 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to Trustees of Dartmouth College. The grant, effective June 6, 2025 through February 28, 2027, supports research to investigate how variations in the morphology of the common mold Aspergillus fumigatus impact the ability to diagnose invasive pulmonary aspergillosis, a serious fungal infection. The research aims to 1) determine...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $410,000 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to The Trustees of Princeton University. The project, titled "Examining the Influence of Chromosome Copy Number on Pseudomonas aeruginosa Persisters to Fluoroquinolones," will investigate how the number of chromosome copies in individual P. aeruginosa bacteria impacts their tolerance to fluoroquinolone antibiotics....
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $299,946 Project Grant to Microbiotix, Inc. under the Allergy and Infectious Diseases Research program (CFDA 93.855) to develop a novel series of benzyl-piperidine antifungal agents to treat intractable Mucorales infections. The goal is to chemically optimize this lead compound series to improve its drug-like properties and antifungal activity against Mucor species, a highly aggressive and often fatal fungal pathogen...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $151,040 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to Brown University. The grant, titled "TAC1 TANGO: EVOLUTIONARY REWIRING OF A TRANSCRIPTIONAL CIRCUIT FOR AZOLE DRUG RESISTANCE IN CANDIDA AURIS", aims to investigate how the emerging fungal pathogen Candida auris has evolved widespread resistance to azole drugs and increased environmental stress tolerance. The research will map the regulatory relationships in azole resistance circuits mediated by the transcription factors TAC1A and TAC1B to attribute the changes in C. auris phenotypes to alterations in regulatory elements or target gene functions. The project will run from February 20, 2026 through October 31, 2027 and is expected to provide insights that could improve therapeutic outcomes and disease threat assessments for this multi-drug resistant fungal infection.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $75.5k | 8/20/25 | ||
| Not listed | $0 | 8/20/25 | ||
| Not listed | $75.5k | 8/20/25 |