This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $466,125 to New York University (NYU) to develop a biologically relevant multi-scale model of brain aging using advanced diffusion MRI (dMRI) techniques. The project aims to generate brain charts of quantitative dMRI and mesoscopic MRI (mesoMRI) markers across the lifespan, creating a brain microstructure age framework. This framework will then be used to evaluate the effects of...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) to the Trustees of Boston University, doing business as Boston University Medical Campus, provides $2,330,859.00 in funding to study age-related changes in brain network connectivity and their relationship to cognitive decline. The 3-year project aims to use multimodal neuroimaging, single-cell transcriptomics, electrophysiology, and neural tract-tracing in a rhesus monkey model to delineate how...
This Project Grant award, identified as R01AG092219, was provided by the National Institute on Aging (NIA) under the Aging Research federal grant program (CFDA 93.866). The $685,404 award will fund a longitudinal study to characterize changes in large-scale functional brain network organization across the mouse lifespan using resting-state fMRI. The research aims to elucidate the mechanisms underlying age-related brain network changes and their relationship to behavior and cognition. The study...
The National Institute on Aging (NIA) awarded a $137,895 Project Grant under the Aging Research federal grant program (CFDA 93.866) to the University of California, Berkeley (UC Berkeley) with a project period from December 3, 2024 to July 31, 2027. The grant will fund a study to investigate how brain network connectivity is associated with Alzheimer's disease (AD) risk, longitudinal pathology accumulation, and aging. Specifically, the project will use positron emission tomography (PET)...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $136,778 to Wake Forest University Health Sciences to conduct research on the impact of cerebral small vessel disease on brain networks and cognitive impairment. The 5-year project aims to: 1) Utilize advanced brain network modeling to understand the resilience and disruption caused by cerebral microbleeds, 2) Develop an integrative machine learning model to improve prediction of...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) to the University of Southern California provides $622,401 over 5 years starting January 1, 2025 to research causal models of brain biomarker changes leading to Alzheimer's disease and related dementias (ADRD). The project aims to: 1) fit novel deep learning models to predict ADRD pathology from diffusion MRI data, 2) generate individualized brain morphology prediction maps as "digital...
The National Institute on Aging (NIA), part of the Department of Health and Human Services National Institutes of Health, awarded a $3.37 million Project Grant to The University of Texas at Arlington to develop an individualized deep connectome framework for Alzheimer's disease and related dementias (ADRD) analysis. The three-year grant, awarded on August 18, 2022 under the NIA's Aging Research program (CFDA 93.866), will support research to discover and identify individualized...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $514,216 to Texas A&M University to conduct research on brain connectomics and their relationship to cognitive aging and Alzheimer's disease vulnerability. The key research goals are to: 1) Examine how changes in brain functional and structural connectivity measures (connectomes) are associated with changes in cognitive performance over time, serving as potential biomarkers of cognitive...
This Project Grant award from the National Institute on Aging (NIA), under the Aging Research federal grant program (CFDA 93.866), is focused on advancing the understanding of attentional resilience in older adults, particularly in the context of delirium and Alzheimer's disease. The $3,871,366 award to Duke University, spanning from August 2024 to April 2029, will evaluate the neural mechanisms underlying attentional control and how they contribute to maintaining cognitive function despite...
This Project Grant from the National Institutes of Health's National Institute on Aging, under the Aging Research program (CFDA 93.866), provides $4,638,424 to the University of California, San Diego from August 1, 2022 to July 31, 2025. The grant will support research developing novel quantitative magnetic resonance imaging techniques to directly image myelin and quantify myelin content and properties in the brain. Specifically, the researchers will use ultra-short echo time sequences with echo...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will fund a study to examine how high-resolution diffusion imaging can provide new insights into age-related changes in white matter connectivity and their impact on cognitive function and brain network dynamics. The $300,892 award to Duke University, which runs from October 2024 through April 2027, will support research across three aims: 1) comparing standard and high-resolution diffusion imaging measures in relation to age and cognitive performance in healthy adults, 2) examining how these imaging measures relate to functional brain connectivity, and 3) evaluating the sensitivity of high-resolution diffusion imaging to detect white matter disconnection and aberrant structure-function relationships in Alzheimer's disease. The goal is to leverage advanced neuroimaging techniques to enhance understanding of the neural mechanisms underlying cognitive aging and Alzheimer's disease.