This $143,784 Project Grant award from the National Institute on Alcohol Abuse and Alcoholism (NIAAA), under the Alcohol Research Programs (CFDA 93.273) federal grant program, supports research to investigate the effects of adolescent opioid exposure on alcohol-induced pain sensitivity (hyperalgesia) in adult mice. The primary objectives are to test the hypothesis that early-life opioid exposure will increase the magnitude of alcohol-induced pain sensitivity in adulthood, and that this effect...
This federal Project Grant award from the National Institute on Alcohol Abuse and Alcoholism (NIAAA), under the Alcohol Research Programs (CFDA 93.273) grant program, provides $144,362 to the University of Pittsburgh to investigate the neural mechanisms underlying chronic alcohol exposure and pain. The key research objectives are to: 1) Determine the activity of neuropeptide Y receptor 1 (Y1)-expressing neurons in the parabrachial nucleus (PBN) during alcohol withdrawal and nociception, and 2)...
This federal Project Grant award from the National Institute on Alcohol Abuse and Alcoholism (NIAAA), under the Alcohol Research Programs (CFDA 93.273) federal grant program, provides $503,750.00 to investigate the effects of chronic pain on alcohol consumption behaviors in heavy drinking individuals with chronic temporomandibular disorder (TMD) pain. The primary objectives are to determine the impact of pain on drinking topography, both in a controlled laboratory environment using virtual...
This $194,551 Project Grant award, funded by the National Institute on Alcohol Abuse and Alcoholism (NIAAA) under the Alcohol Research Programs (CFDA 93.273), will support research at the Medical University of South Carolina (MUSC) to investigate the regulation of a neural pathway involved in pain processing following adolescent intermittent ethanol exposure. The overarching goal is to determine how persistent changes in synaptic function within the prelimbic cortex (PRL) and ventrolateral...
This federal Project Grant award, provided by the National Institute on Alcohol Abuse and Alcoholism (NIAAA) under the Alcohol Research Programs (CFDA 93.273), supports research on the role of BNST PKCδ neurons in compulsive ethanol intake behaviors. The $156,204 award, with a period of performance from May 15, 2025 to April 30, 2027, will fund a study using in vivo fiber photometry and ex vivo slice wide-field calcium imaging to evaluate adaptations in BNST PKCδ neuron activity across ethanol...
This $498,121.57 Project Grant award from the National Institute on Alcohol Abuse and Alcoholism (NIAAA), under the Alcohol Research Programs (CFDA 93.273), will support research to investigate the neural mechanisms that drive maladaptive coping strategies and subsequent alcohol use following exposure to stress. The principal investigator will utilize an animal model to study how dysfunction in the corticolimbic circuitry, specifically the prelimbic cortex and basolateral amygdala, contributes...
This federal Project Grant award from the National Institute on Alcohol Abuse and Alcoholism (NIAAA), under the Alcohol Research Programs (CFDA 93.273), provides $497,581.76 in funding to Yale University to conduct research on avoidance learning and pain circuit dysfunction in alcohol use disorders (AUD). The key objectives of this 3-year study are to: 1) characterize dysfunctions in brain circuits supporting pain reactivity and cognitive control during avoidance learning in AUD patients...
The National Institute on Alcohol Abuse and Alcoholism (NIAAA) awarded a $275,171.12 Project Grant under the Alcohol Research Programs (CFDA 93.273) to the University of California, Los Angeles (UCLA) on July 24, 2024. The grant will support a clinical neuroscience study to understand stress coping mechanisms in individuals with Alcohol Use Disorder (AUD) compared to matched controls. The research aims to objectively assess chronic stress and examine dynamic functional connectivity within the...
This federal Project Grant award from the National Institute on Alcohol Abuse and Alcoholism (NIAAA), under the Alcohol Research Programs (CFDA 93.273), provides $197,262 to the University of Missouri System for a study examining the effects of cannabis use on community-based alcohol treatment outcomes among adolescents. The study aims to use mixed methods, including qualitative interviews and ecological momentary assessment, to understand how cannabis use relates to alcohol use disorder and...
This Project Grant award, totaling $179,154, was provided by the National Institute on Alcohol Abuse and Alcoholism (NIAAA) under the Alcohol Research Programs (CFDA 93.273) federal grant program. The award's objective is to elucidate novel mechanisms of alcohol-induced fibrotic gene reprogramming in the liver and identify specific factors amplifying hepatic stellate cell activation in alcohol-related liver disease. The awardee, the University of Colorado-Denver, will conduct research to...