Project Grant F31MH144977
- The National Institute of Mental Health awarded Thomas Jefferson University $431,750 on May 15, 2026, under the Mental Health Research Grants program (CFDA 93.242) to characterize the role of DNA-dependent protein kinase (DNA-PK) in HIV latency and transcription within central nervous system microglial cells, the primary CNS reservoir for HIV. The research aims to define the molecular mechanisms by which DNA-PK supports HIV transcription in microglial cells and to test the hypothesis that DNA-PK...
- The National Institute of Mental Health awarded $1,518,208 to Rush University Medical Center on April 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to develop and employ a human-mouse chimera model for studying HIV infection in the central nervous system and HIV-associated neurocognitive deficits in antiretroviral therapy-treated patients. The award supports research that models the dynamics of HIV crossing the blood-brain barrier into the brain, the resulting...
- The National Institute of Mental Health awarded the University of California, Los Angeles $787,498 under the Mental Health Research Grants program (CFDA 93.242) on July 1, 2026, to characterize HIV persistence and neuroinflammation in central nervous system (CNS) reservoirs in vivo using barcoded HIV tracking, spatial transcriptomics, single-cell RNA sequencing, and integration site analysis. The research investigates the contributions of T cell populations in HIV persistence and inflammation...
- The National Institute of Mental Health awarded The Trustees of The University of Pennsylvania $1,217,055 on July 17, 2026, under the Mental Health Research Grants program (CFDA 93.242) to investigate selective inhibition of T cell trafficking to the brain during acute SHIV infection in rhesus macaques. The research leverages a validated nonhuman primate model of HIV neuropathogenesis and persistence to determine how blocking T cell circulation during acute SHIV.D infection affects the...
- The National Institute of Mental Health awarded The Johns Hopkins University $149,190 on August 2, 2026, under the Mental Health Research Grants program (CFDA 93.242) to identify intervention opportunities in the continuum of cognitive impairment among persons aging with HIV. The research will estimate the proportion of cognitive impairment cases among people with HIV potentially attributable to psychosocial and behavioral risk factors, prioritizing those interventions that could prevent the...
- The National Institute of Mental Health awarded The University of Texas Southwestern Medical Center $1,645,997 on September 22, 2025, under the Mental Health Research Grants program (CFDA 93.242) to conduct positron emission tomography imaging research examining microglial proliferation and its relationship to executive function and cognitive control deficits in virally-suppressed people with HIV. The project, titled "Imaging Microglia in Virally-Suppressed HIV," uses [11C]DPA-713...
- The National Institute of Mental Health awarded the University of North Carolina at Chapel Hill $793,185 on April 7, 2026, under the Mental Health Research Grants program (CFDA 93.242) to investigate inactivation of the ISR/ATF4 signaling pathway as a mechanism to stabilize and reduce HIV reservoirs in latently infected cells. The award funds research into how the integrated stress response and ATF4 transcription factor regulate HIV transcription and latency. The project will characterize how...
- The National Institute of Neurological Disorders and Stroke awarded the University of Colorado a Project Grant totaling $184,506 on August 7, 2025, under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. This two-year award, with an ultimate completion date of July 31, 2027, supports research investigating the dual roles of amyloid beta (AB) in central nervous system neuropathogenesis associated with HIV-Associated Neurocognitive Disorder...
- The National Institute of Mental Health awarded Albert Einstein College of Medicine $149,190 on September 11, 2026, under the Mental Health Research Grants program (CFDA 93.242) to characterize the effects of the kynurenine pathway on blood-brain barrier disruption and CD14+CD16+ monocyte function in people with HIV and comorbid depression. The project investigates neurobiological mechanisms linking HIV-associated depression to activation of the kynurenine pathway, a metabolic process implicated...
- The National Institute of Mental Health awarded the University of Alabama at Birmingham $1.809 million on June 5, 2026, under the Mental Health Research Grants program (CFDA 93.242) to develop novel preclinical models of neuroHIV that incorporate antiretroviral therapy suppression dynamics. The award funds development of next-generation neuroHIV models composed of autologous peripheral human immune cells, relevant human glial cell types, and an intact blood-brain barrier in the context of...
The National Institute of Mental Health awarded Drexel University $100,228 on December 16, 2026, under the Mental Health Research Grants program (CFDA 93.242) to support research on HIV-induced trained immunity in microglia and its contribution to HIV-associated neurocognitive disorders (HAND). The project investigates whether trained immunity—a form of innate immune memory characterized by hyperresponsiveness to secondary inflammatory stimulation—occurs in microglial cells of people living with HIV and drives or exacerbates neuroinflammation and HAND progression. Despite widespread antiretroviral therapy use, up to 50 percent of people living with HIV experience HAND, which can progress to HIV-associated dementia, particularly with advancing age. The research explores epigenetic and metabolic mechanisms underlying trained immunity in microglia, drawing on preliminary data showing that exposure to HIV-1 induces trained immunity in microglial cell lines and published microglial gene expression signatures consistent with trained microglia signatures documented in other contexts. The work is performed in Philadelphia, Pennsylvania, with a period of performance extending through June 18, 2028. This assistance type is a project grant supporting basic research within the National Institute of Mental Health's mission to transform understanding and treatment of mental illness through research.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $50.1k | 6/19/26 | ||
| Not listed | $0 | 6/19/26 | ||
| Not listed | $50.1k | 6/19/26 |