Federal Grant Award Summary

Emory University received a $100,228 Project Grant award from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242), effective November 8, 2026, through May 13, 2029. The award funds basic neuroscience research investigating how the lateral septum-ventral tegmental area (LS-VTA) neural circuit projection modulates reward-seeking behavior and learning. The research aims to elucidate the mechanisms by which the lateral septum influences reward prediction error signaling in dopamine neurons of the ventral tegmental area, with particular focus on understanding how this circuit contributes to reward learning and behavioral adaptation. By clarifying these neural circuit mechanisms underlying reward processing, the project seeks to identify potential therapeutic targets for psychiatric disorders characterized by dysfunctional reward seeking, including major depressive disorder and substance use disorder.

The research plan employs cellular-resolution calcium imaging and operant behavioral assays to examine the LS-VTA neural population during reward-seeking tasks. The findings are intended to advance fundamental understanding of reward neurobiology and ultimately inform the development of new treatment approaches for mental illnesses affecting reward motivation and learning. This project contributes to NIMH's broader mission to transform the understanding and treatment of mental illnesses through basic and clinical research.