Defining the metabolic regulation of erythropoiesis
Ended Project Grant Awarded Last action
- Award ID
- F31HL172674
- Recipient
-
Regents Of The University Of Michigan UEI GNJ7BBP73WE9
- Awarding agency
-
National Heart Lung and Blood Institute
National Institutes of Health, Department of Health and Human Services
- Obligated
- $219,643
Award facts
- Assistance listing
- 93.837 Cardiovascular Diseases Research
- Completion date
- Place of performance
- Ann Arbor, MI 48109, USA
Award details come from USAspending.gov.
Description
- Abstract
- The metabolic state of hematopoietic stem cells is an important contributor to self-renewal, however the metabolic changes controlling the differentiation of hematopoietic stem cells to erythrocytes is poorly understood. Here, i show preliminary data that that the malate-aspartate shuttle (MAS) impacts early erythropoiesis. The MAS is a well-studied mechanism in cells that transfers electrons in the form of nadh from the cytosol into the mitochondria, specifically, disruption of the shuttle in vivo through conditional deletion of one its enzyme in an erythroid progenitor leads to significant anemia. Accordingly, i hypothesize that the MAS is required for redox homeostasis during early erythroid development and that failure of the MAS paves way for ineffective erythropoiesis. Aim i works to determine which erythroid differentiation stages requires the MAS. Aim II defines the molecular mechanism by which the MAS impacts erythropoiesis. For these, i am using both in vivo mouse models and in vitro CD34+ hematopoietic stem and progenitor cells. Together, these aims investigate whether reductive stress through the MAS during early erythropoiesis is an important contributor to ineffective erythropoiesis.
Transactions
| Action | Obligated | Date |
|---|---|---|
| Amendment | -$30,925 | |
| Amendment | $564 | |
| Amendment | $42,094 | |
| Amendment | $42,094 | |
| Amendment | $1,280 | |
| Amendment | $1,280 | |
| Amendment | $40,814 | |
| Amendment | $0 | |
| Amendment | $40,814 | |
| Amendment | $40,814 | |
| Amendment | $0 | |
| Amendment | $0 | |
| Original award | $40,814 |
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Quick answers
Who received award F31HL172674?
F31HL172674 was awarded to Regents Of The University Of Michigan by National Heart Lung and Blood Institute (National Institutes of Health) on August 1, 2024.
How much is award F31HL172674 worth?
$219,643 has been obligated on F31HL172674.
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