Macrophage-mediated lung repair programs following injury

Active Project Grant Awarded Last action

Award ID
F31HL172650
Recipient
Awarding agency
Obligated
$373,874

Award facts

Assistance listing
93.837 Cardiovascular Diseases Research
Completion date 90% complete
Place of performance
Cambridge, MA 02138, USA

Award details come from USAspending.gov.

Description

As the agency reported it.

Abstract
Over the past several years, we have experienced the social and physical consequences of a viral pandemic; however, the cellular and molecular mechanisms of repair following such infections are not fully understood. The lung serves as the site of gas exchange. Due to this function, IT is constantly exposed to noxious environmental stimuli-including bacteria and viruses. Following viral respiratory infection, many of the epithelial cells lining the airways are lost and must be reconstituted. The epithelial-intrinsic mechanisms underlying such recovery are well understood, but the role of the immune system in this process is not well defined. In close contact with epithelial cells in the distal lung are alveolar macrophages, innate immune cells capable of sensing diverse stimuli and integrating these signals into effector responses. Our previous work has shown that macrophages engage in reciprocal growth factor exchange with fibroblasts, a communication circuit we predict to be active in other cell types and contexts. In the lung, macrophages have been observed to help mediate inflammation and repair via communication with epithelial cells following injury, however, the role of these interactions in the context of viral infection remains unknown. Using a mouse-adapted influenza a virus, we observe a marked loss of epithelial cells followed by rapid recovery, all under a constant presence of macrophages. This study aims to determine the role of macrophages in this repair process. We hypothesize that optimal epithelial repair requires macrophages at specific time points and anatomical locations following viral-induced damage. We also propose that bidirectional crosstalk between macrophages and epithelial cells promotes tissue repair. The proposed work will serve to 1) define when and where macrophages are required for optimal repair following viral injury and 2) provide mechanistic understanding of macrophage-epithelial communication networks in the injured and regenerating lung. Completion of this project will allow US to identify molecular targets whose modulation may improve patient outcomes following viral infection. The franklin lab is the ideal research environment to perform these studies. DR. Franklin (sponsor) is an expert in macrophage biology and has previously unraveled interactions between macrophages and non-immune cells. Our location at harvard medical school also grants access to world-class experts and resources to complete our aims. For example, DR. Carla KIM (CO-sponsor) is an expert on lung damage and repair and will provide guidance on lung biology and epithelial progenitor cell function following damage. Together, my mentoring team and institutional resources will help me achieve the goals outlined in this proposal and allow me to grow both as a scientist and an individual.

Transactions

Action Obligated Date
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Quick answers

Who received award F31HL172650?

F31HL172650 was awarded to President And Fellows Of Harvard College by National Heart Lung and Blood Institute (National Institutes of Health) on June 22, 2024.

How much is award F31HL172650 worth?

$373,874 has been obligated on F31HL172650.

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