Ptsd-induced alterations on cardiac homeostasis
Ended Project Grant Awarded Last action
- Award ID
- F31HL170740
- Recipient
-
The Medical University Of South Carolina UEI NHV3GTWSALA7
- Awarding agency
-
National Heart Lung and Blood Institute
National Institutes of Health, Department of Health and Human Services
- Obligated
- $291,848
Award facts
- Assistance listing
- 93.837 Cardiovascular Diseases Research
- Completion date
- Place of performance
- Charleston, SC 29425, USA
Award details come from USAspending.gov.
Description
- Abstract
- Cardiovascular disease (CVD) is the leading cause of death in the united states. Multiple studies indicate that post-traumatic stress disorder (ptsd) is a risk factor for CVD. Clinical studies suggest that ptsd stimulates chronic and uncontrolled inflammation through various cytokines and immune cells like macrophages and matrix metalloproteinase (MMP)-9. While these presented studies highlight associations, literature is lacking in mechanisms connecting both CVD and ptsd, leaving patients vulnerable to CVD associated events. Accordingly, the proposed study aims to determine the association between ptsd-induced chronic inflammation and the resetting of cardiac homeostasis. The central hypothesis is that ptsd stimulates recruitment of monocyte-derived macrophages to the heart, resulting in increased cardiac fibrosis and resetting cardiac homeostasis via MMP-9 dependent mechanism. Aim 1 will test the hypothesis that monocyte specific MMP-9 stimulates ptsd-mediated cardiac remodeling and dysfunction. Aim 2 will test the hypothesis that ptsd-induced hyperactivation of monocytes stimulate fibroblast ECM production. Together the data will provide a foundation for future mechanistic studies between CVD and ptsd to further the fields of both cardiology and neuroscience. Collectively, the proposed studies align with the mission of NIH and nhlbi and will enhance overall health, quality of life, and reduce disability.
Transactions
| Action | Obligated | Date |
|---|---|---|
| Amendment | $564 | |
| Amendment | $48,974 | |
| Amendment | $48,974 | |
| Amendment | $1,280 | |
| Amendment | $1,280 | |
| Amendment | $47,694 | |
| Amendment | $47,694 | |
| Amendment | $0 | |
| Amendment | $0 | |
| Amendment | $47,694 | |
| Amendment | $47,694 | |
| Original award | $0 |
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Quick answers
Who received award F31HL170740?
F31HL170740 was awarded to The Medical University Of South Carolina by National Heart Lung and Blood Institute (National Institutes of Health) on September 30, 2024.
How much is award F31HL170740 worth?
$291,848 has been obligated on F31HL170740.
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