Project Grant F31DK149594
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded the University of Pittsburgh $698,501 on September 1, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to identify gene-level interactions between host immunity and the intestinal microbiota that regulate inflammation in inflammatory bowel disease. The funded research combines microbiota analysis tools, host single-cell RNA sequencing, and machine learning methods to...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded Duke University $612,587 on March 18, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to investigate the mechanisms by which the microbiome regulates postnatal growth and lipid metabolism in extremely preterm infants. The research addresses growth failure in extremely preterm infants, a condition independently associated with adverse neurodevelopmental outcomes. The...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded the University of California, Davis $180,109 on June 1, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to investigate restoration of microbiota signaling pathways using non-biotic substitutes—termed "faux-biotics"—to control opportunistic infections during chemotherapy-induced dysbiosis. The project addresses the loss of colonization resistance that occurs...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded California Institute of Technology $661,126 on August 21, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847, Assistance Listing Project Grant R01DK149061). The award funds bacterial metatranscriptomics research aimed at resolving contributions of host and microbial pathways to human health and disease. Tissue-associated microbes play fundamental roles in shaping host...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded The University of Texas MD Anderson Cancer Center $151,136.00 on April 1, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to conduct multi-omic analyses of the gut microbiome and its relationship to metabolic dysfunction-associated steatotic liver disease (MASLD). The research integrates metagenomic, metabolomic, and metatranscriptomic analyses to explore microbial...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded The Washington University $821,816 on September 1, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to investigate the microbial contributors to hematopoiesis and the mechanisms by which commensal intestinal bacteria maintain normal blood cell production. The research interrogates how depletion of commensal bacteria causes cytopenias (low peripheral blood counts) in...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded North Carolina State University $738,169 on June 1, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to investigate methanogen-bacterial syntrophy and its role in digestive health. The research examines interdomain syntrophic partnerships between methanogenic archaea and bacteria in the human microbiome, with focus on how dysfunction in these relationships drives...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded $127,206 to The Washington University on April 5, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The research investigates Prevotella copri-mediated effects of dietary glycan supplementation on microbial community and host metabolism in the context of treating childhood undernutrition. The work builds on clinical trial evidence that microbiota-directed complementary...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded the University of California, Davis $739,895 on September 1, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to investigate neonatal development of the microbiota-gut-brain axis. The research addresses how bacterial colonization of the gastrointestinal tract, formation of the GI mucosal barrier, and neurogenesis during early life establish a critical developmental...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded $121,125 to the University of Virginia on May 1, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to engineer and optimize a three-dimensional microfluidic co-culture system that models the gut-on-chip and investigates how biomechanical forces—specifically stretch and stiffness—affect enteric neurons and glia. The project addresses chronic idiopathic constipation and...
The National Institute of Diabetes and Digestive and Kidney Diseases awarded Emory University $100,228 on April 15, 2027, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The research evaluates deterministic strain interactions and stochasticity in gut microbiomes using a specialized host-microbe model system pairing squash bugs (Anasa tristis) with their mutualistic gut bacterium (Caballeronia spp.). The project assesses how bacterial competition and neutral stochasticity influence microbiome assembly during gut colonization, maintenance, and transmission. Work includes culturing defined multi-strain bacterial communities and inoculating them into Caballeronia-free hosts to evaluate competitive and stochastic colonization patterns. The research examines how bacterial motility and biofilm production mediate strain interactions and competition in both naive and perturbed microbiomes, with the hypothesis that both selective forces from strain competition and neutral forces from stochastic processes drive microbiome simplification during establishment, maintenance, and following perturbations. Performance occurs in Atlanta, Georgia, with a period of performance from April 15, 2027, through August 31, 2029. This is a Project Grant assistance type.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $0 | 8/14/26 | ||
| Not listed | $50.1k | 8/14/26 |