Project Grant F31DK148130
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded Baylor College of Medicine $200,000 on September 15, 2025, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847, assistance type Project Grant). The funded research investigates how proteostatic stress—arising from fever-range hyperthermia, altered oxygen tension, and modulation of protein quality control pathways including chaperones, proteasome activity, autophagy, and...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded Dana-Farber Cancer Institute, Inc. $740,581 on April 1, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to fund basic research on niche regulation of gastric epithelial cell differentiation. The award funds investigation of how distinct stomach epithelial cell types—pit, isthmus, neck, and chief cells—arise from a common multipotential progenitor and are regulated by...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded Baylor College of Medicine $149,190 on December 6, 2025, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to conduct basic research modeling intestinal stem cell regulation during aging. The recipient will use Drosophila melanogaster to investigate mechanisms controlling the transition between active and quiescent states in intestinal stem cells, with particular focus on a...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded the Scripps Research Institute $152,600 on February 15, 2027, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The award funds research examining how hepatic endoplasmic reticulum (ER) stress affects the integrity of the secreted proteome, with focus on protein aggregation diseases including systemic amyloidoses. The research will use established and novel proteomics...
- The National Institute of Diabetes and Digestive and Kidney Diseases, part of the Department of Health and Human Services National Institutes of Health, awarded Baylor College of Medicine $167,165 on July 2, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to investigate molecular mechanisms of T cell dysfunction in pediatric chronic cholestatic liver diseases. The research program, spanning five years through March 31, 2031, and performed in...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded Brigham & Women's Hospital Inc. $730,898 on July 10, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to investigate NR5A2 regulatory mechanisms in pancreas health and disease. The research examines how the transcription factor NR5A2 governs acinar cell identity and its role in preventing acinar-to-ductal metaplasia, a reversible process occurring during acute...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded The Leland Stanford Junior University $611,189 on September 3, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to investigate the molecular mechanisms of epithelial symmetry breaking and repair. The research examines the roles of E-cadherin and PAR-3 proteins in establishing apical-basolateral polarity within epithelial tissues. The study focuses on how unpolarized...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded the University of Alabama at Birmingham $718,880 on August 10, 2026, to investigate pancreatic regeneration in conditions caused by genetic mutation under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The research develops and utilizes a novel animal model that mimics pancreatic injury and healing in individuals with cystic fibrosis caused by a specific CF gene mutation. The...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded Baylor College of Medicine $240,000 on August 27, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to develop preclinical mouse models expressing HIV proteins that replicate metabolic comorbidities observed in persons living with HIV, including obesity, cardiovascular disease, chronic kidney disease, osteoporosis, cancers, frailty, and cognitive decline. The research...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded Pennsylvania State University (operating as Penn State Milton S. Hershey Medical Center) $163,665 for a five-year career development and research program on August 1, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The research investigates gastric zymogenic cell plasticity and the role of YAP1 and TAZ proteins in governing the balance between tissue regeneration and...
The National Institute of Diabetes and Digestive and Kidney Diseases awarded Baylor College of Medicine $100,228 on February 1, 2027, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to investigate the roles and dynamics of the endoplasmic reticulum during paligenosis and metaplasia formation. The project examines upstream triggers of paligenosis—an evolutionary conserved process in which differentiated cells downscale organelle contents, activate progenitor-like gene networks, and reenter the cell cycle to enable cellular renewal in adult organs lacking dedicated stem cells. Using a high-dose tamoxifen injury model in murine stomach corpus zymogenic chief cells, the research documents ultrastructural changes in rough endoplasmic reticulum during paligenosis initiation, including lamellae swelling, ribosome liberation, and overall ER loss. The work tests the hypothesis that dynamic ER changes constitute an upstream paligenosis event. Preliminary data indicate that the integrated stress response pathway—specifically the PERK kinase and its phosphorylation of the translation initiation protein eIF2A—triggers global attenuation of protein synthesis and early ER disassembly in paligenotic cells, suggesting that PERK-integrated stress response mechanisms drive early paligenosis events. Work is performed in Houston, Texas with a period of performance from February 1, 2027 through June 30, 2027.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $50.1k | 6/23/26 | ||
| Not listed | $50.1k | 6/23/26 | ||
| Not listed | $0 | 6/23/26 |