Neural mechanisms of speech motor inhibition in stuttering
Active Project Grant Awarded Last action
- Award ID
- F31DC023765
- Recipient
-
University Of Delaware UEI T72NHKM259N3
- Awarding agency
-
National Institute on Deafness and Other Communincation Disorders
National Institutes of Health, Department of Health and Human Services
- Obligated
- $94,452
Award facts
- Assistance listing
- 93.173 Research Related to Deafness and Communication Disorders
- Completion date 3% complete
- Originally
- Place of performance
- Newark, DE 19713, USA
Award details come from USAspending.gov.
Description
- Abstract
- Developmental stuttering is a neurodevelopmental speech disorder that affects approximately 5-8% of children, with many continuing to stutter into adulthood. One of the most clinically impactful features of stuttering is the sudden inability to initiate speech, often described as being "stuck." emerging evidence suggests that this disruption may reflect inappropriate engagement of motor inhibition mechanisms. In particular, the basal ganglia- thalamocortical (bgtc) loops, including the hyperdirect and indirect pathways, are thought to support different forms of inhibitory control, but their roles in stuttering remain poorly understood. The goal of this project is to determine whether motor inhibition circuits are engaged during both the voluntary inhibition of speech initiation and moments of stuttering. This study uses a novel design and utilizes high- resolution fmri and EEG, in separate sessions, to examine neural activity in key regions implicated in inhibitory control (pre-SMA, rifg, and STN). A participant-tailored stop-signal task will be used to elicit both the voluntary inhibition of speech initiation and moments of stuttering in the same individuals. Two primary aims will be addressed: (1) to identify shared and distinct neural markers of voluntary inhbition of speech initiation and stuttering, and (2) to assess whether individual differences in these neural responses predict stuttering frequency, anticipation, and psychosocial impact. By directly linking neural dynamics to real-world stuttering behaviors and experiences, this project advances mechanistic understanding of speech motor inhibition and its dysregulation in stuttering. Findings will clarify the contributions of the indirect and hyperdirect pathways to speech inhibition and lay the foundation for individualized and targeted interventions. Results may also inform broader models of motor control and inhibition, with potential relevance for related disorders such as parkinson's disease.
Transactions
| Action | Obligated | Date |
|---|---|---|
| Amendment | $47,226 | |
| Amendment | $0 | |
| Original award | $47,226 |
Quick answers
Who received award F31DC023765?
F31DC023765 was awarded to University Of Delaware by National Institute on Deafness and Other Communincation Disorders (National Institutes of Health) on September 30, 2026.
How much is award F31DC023765 worth?
$94,452 has been obligated on F31DC023765.
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