Project Grant F31CA298229
Award Date 12/1/25
Completion Date 5/31/27
Dollars Obligated $128K
Federal Agency
Federal Grant Program
Assistance Type
Project Grant
Place of Performance
Michigan, USA
Similar Awards
- The University of Michigan was awarded a $2,284,054 Project Grant by the National Cancer Institute (NCI) under the Cancer Detection and Diagnosis Research (CFDA 93.394) federal grant program. The 4-year grant, which began on September 1, 2025, will support research to transform molecular cancer screening through the development of stimulated Raman histology and deep neural networks. The project aims to improve access to molecular cancer testing by creating innovative diagnostic tools and methods...
- This $238,722 federal Project Grant awarded on August 18, 2025 by the National Cancer Institute (CFDA 93.398 - Cancer Research Manpower) to the Sloan-Kettering Institute for Cancer Research supports research to investigate the role of mutagenic DNA repair during the persistence of cancer cells. The research aims to define the specific mechanisms that promote mutagenic DNA repair and drive acquired drug resistance in persister cancer cells, focusing on the role of the microhomology-mediated end...
- This federal Project Grant award, with an ID of HT94252410974, was provided by the Defense Health Agency under the Military Medical Research and Development (CFDA 12.420) program. The $1,390,569.00 award supports research focused on the "THERAPEUTIC MODULATION OF THE SERINE/THREONINE PHOSPHATASE PP2A TO PREVENT RESISTANCE TO MAPK INHIBITOR THERAPY IN NSCLC", with a performance period from November 1, 2024 to October 31, 2027. The award recipient is the Regents of the University of...
- This $640,135 federal Project Grant award from the National Cancer Institute (CFDA 93.395 - Cancer Treatment Research) supports research to develop a new generation of potent menin inhibitors that can overcome resistance observed in current menin inhibitor treatments for acute myeloid leukemia (AML) patients. The award recipient, the Regents of the University of Michigan, will leverage its expertise in medicinal chemistry and cancer biology to design and test these next-generation menin...
- This federal Project Grant award of $128,199 from the National Cancer Institute's Cancer Research Manpower program (CFDA 93.398) supports research by the Regents of the University of Michigan to investigate the role of the lipid kinase PIKFYVE in regulating metabolic homeostasis in pancreatic ductal adenocarcinoma (PDAC). The research aims to 1) dissect PIKFYVE's function in PDAC metabolism, and 2) determine the mechanism and efficacy of combining PIKFYVE inhibition with KRAS-MAPK inhibition...
- This Project Grant award of $439,049 was provided by the National Cancer Institute (CFDA 93.395 - Cancer Treatment Research) to Oakland University in Michigan. The funding supports research to investigate the role of the PTEN protein phosphatase in regulating the ubiquitination and autophagy of SNAIL/SLUG transcriptional repressor proteins within intestinal epithelial cells. The research aims to elucidate how PTEN deficiency can induce preclinical dysplasia in the intestine, and how loss of...
- This Project Grant award from the National Cancer Institute (CFDA 93.398 - Cancer Research Manpower) provides $123,850 to the Regents of the University of Michigan to investigate the role of H3F3A and ATRX co-mutation in epigenetic dysregulation of developmental genes in pediatric high-grade glioma. The researchers will assess how loss of ATRX impacts developmental gene expression in H3G34R/V mutant tumor cells, hypothesizing that co-mutation will lead to inappropriate PRC2 localization and...
- This Project Grant from the National Cancer Institute, part of the Department of Health and Human Services, provided $136,080 under the Cancer Research Manpower federal grant program (CFDA 93.398) to Dana-Farber Cancer Institute from May 3, 2021 through July 15, 2021. The grant supported research aimed at determining the three-dimensional protein structures of phosphatase 2A holoenzyme complexes formed in response to perphenazine and related small molecules, to elucidate the mechanisms by...
- This $462,153 Project Grant was awarded on September 4, 2025 by the National Cancer Institute under the Cancer Biology Research program (CFDA 93.396) to Northern Michigan University (NMU). The grant will fund the development and utilization of a novel genetically encoded fluorescent biosensor, D2HGLO, to quantify intracellular concentrations of the oncometabolite d-2-hydroxyglutarate (d-2-HG) in cancer cells. This innovative tool will allow researchers to study the subcellular localization and...
- This federal Project Grant award from the National Cancer Institute (CFDA 93.396 - Cancer Biology Research) provides $509,246 to the Regents of the University of Michigan to conduct research on early drivers of prostate cancer lineage plasticity. The project aims to identify key transcriptional regulators that repress androgen receptor signaling and promote alternate differentiation programs in prostate cancer, with the goal of preventing lineage plasticity and disease progression. By...