This Project Grant award from the National Cancer Institute (CFDA 93.398 Cancer Research Manpower) provides $134,574.00 to the University of California, Los Angeles (UCLA) to investigate the mechanisms by which aberrant epidermal growth factor receptor (EGFR) signaling suppresses anti-tumor immunity in glioblastoma, the most common and deadly primary brain cancer. The goal is to elucidate how EGFR activation in glioblastoma impairs T cell infiltration and function, and promotes an immunosuppressive tumor microenvironment dominated by immunosuppressive microglia. The research aims to determine the precise impact of EGFR signaling and tumor-programmed myeloid cells on T cell cytotoxicity, proliferation, and exhaustion. It also seeks to understand how EGFR activation coordinates with microglia IL-1β signaling to drive an immunosuppressive phenotype. Ultimately, the project will assess combination strategies targeting EGFR and immune checkpoint blockade to enhance anti-tumor immunity in this deadly malignancy. The award period is from December 24, 2024 to July 31, 2026.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $45.2k | 7/15/25 | ||
| Not listed | $44.7k | 6/24/24 | ||
| Not listed | $44.7k | 6/24/24 | ||
| Not listed | $0 | 6/24/24 |