This $284,201.82 Project Grant from the National Cancer Institute, a division of the Department of Health and Human Services, will fund research into malignant cell engagement in immune circuits of human colorectal cancer. The Broad Institute, Inc. will utilize single cell RNA sequencing data from over 700,000 malignant, immune, and stromal cells from colorectal cancer patients to test the hypothesis that malignant cells expressing interferon-stimulated genes acutely promote anti-tumor immunity,...
This federal Project Grant award in the amount of $204,474.00 was provided by the National Cancer Institute (NCI) under the Cancer Research Manpower (CFDA 93.398) program. The award will support research at the University of Colorado to define the transition between reversible cell quiescence and permanent cellular senescence, which has important implications for understanding cancer drug resistance and developing more effective cancer treatments. The key research objectives are to 1) use...
This federal Project Grant award from the National Cancer Institute (CFDA 93.398 Cancer Research Manpower program) provides $312,892 to Duke University to investigate the role of type 3 innate lymphoid cells (ILC3s) in regulating the melanoma tumor microenvironment. The research aims to better understand how ILC3s can create immunosuppressive conditions that limit the effectiveness of immune checkpoint inhibitor (ICI) therapies for advanced melanoma. By defining the function of ILC3s in the...
This Project Grant award from the National Cancer Institute's Cancer Research Manpower Program (CFDA 93.398) provides $293,369 to Duke University to investigate the mechanisms by which residual tumor cells evade the immune system after treatment with targeted oncogene therapies. The researchers will use integrative transcriptomics and functional genomics approaches to uncover potential targets to enhance the immune-mediated clearance of these residual tumor cells. This research aims to elucidate...
This National Cancer Institute (NCI) Project Grant award under CFDA 93.395 "Cancer Treatment Research" provides $196,267 in funding to the University of California, Irvine (UCI) to advance novel cancer prevention and therapeutic strategies across NCI's clinical trial networks. The award will support the Principal Investigator's leadership roles on key NCI committees, completion of an ongoing Phase III clinical trial focused on preventing colorectal adenomas in a racially/ethnically...
This is a $154,642 Project Grant awarded by the National Cancer Institute (NCI) under the Cancer Research Manpower (CFDA 93.398) federal grant program. The grant supports research to elucidate the evolving immunopeptidome of metastatic colorectal cancer (CRC) and develop engineered T-cell therapies targeting conserved CRC-specific antigens. Key products and services to be delivered include: 1) Systematic analysis of the immunopeptidome from patient-derived CRC organoids across normal colon,...
This Project Grant award of $483,077 from the National Cancer Institute (CFDA 93.396 Cancer Biology Research) will support research at Baylor College of Medicine to investigate the role of the noncanonical clock gene ESRRG in mediating circadian enhancer-promoter interactions during the progression from nonalcoholic fatty liver disease (NAFLD) to hepatocellular carcinoma (HCC). The project aims to use viral vector systems to modulate ESRRG expression rhythms in NAFLD mouse models, determine...
This National Cancer Institute (NCI) Project Grant award under the Cancer Cause and Prevention Research (CFDA 93.393) federal grant program provides $408,913 to the University of California Irvine from August 15, 2024 to July 31, 2029. The project investigates the mechanisms by which genes encoding ribosomal proteins are used as sensors for altered cellular chromosome content in fruit flies, a genetic model system. The research aims to define the molecular basis for cellular recognition and...
This federal Project Grant award from the National Cancer Institute (NCI) under the Cancer Cause and Prevention Research program (CFDA 93.393) provides $103,948 to the Sloan-Kettering Institute for Cancer Research to investigate mechanisms driving T-cell dysfunction and impaired translation in the tumor microenvironment. The research aims to elucidate how local amino acid availability limits effector function in tumor-infiltrating T-cells and how enhancing amino acid transport could improve...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under CFDA Program 93.859 Biomedical Research and Research Training, provides $451,250 to Childrens Hospital Medical Center in Cincinnati, Ohio to investigate the molecular mechanisms that coordinate circadian clock gene expression in brain regions beyond the central pacemaker. The research aims to elucidate how internal and external signals, particularly light exposure, integrate to regulate clock gene...