Mitigating quadriceps atrophy after ACL injury: the role of neuromuscular dysfunction and reactive oxygen species
Active Project Grant Awarded Last action
- Award ID
- F31AR087153
- Recipient
-
Regents Of The University Of Michigan UEI GNJ7BBP73WE9
- Awarding agency
-
National Insititue of Arthritis and Musculoskeletal and Skin Diseases
National Institutes of Health, Department of Health and Human Services
- Obligated
- $88,848
Award facts
- Assistance listing
- 93.846 Arthritis, Musculoskeletal and Skin Diseases Research
- Completion date 0% complete
- Originally
- Place of performance
- Ann Arbor, MI 48109, USA
Award details come from USAspending.gov.
Description
- Abstract
- The purpose of this F31 predoctoral individual national research service award is to support luke stoneback's development into an independent researcher and advance his studies on the neural and oxidative mechanisms driving poor muscle recovery after anterior cruciate ligament (ACL) injury. Under the mentorship of DR. Lindsey lepley and a multidisciplinary advisory team at the university of michigan, luke will gain essential skills in neurophysiology, redox biology, and rehabilitation science to address critical gaps in understanding how ACL injury leads to quadriceps muscle atrophy and weakness. Luke's long-term career goal is to become a productive, independent scientist focused on studying the effects of ACL injury on quadriceps muscle health. The central tenet of his F31 proposal is to investigate the role of reactive oxygen species (ROS) as a driver of poor muscle recovery in response to reduced quadriceps activation following ACL injury. Specifically, this research will document the impact of ACL injury on quadriceps neuromuscular junctions (aim 1), establish the role of elevated ROS in quadriceps atrophy and weakness (aim 2), and test the potential of low-frequency neuromuscular electrical stimulation (nmes) as a novel approach to mitigate ROS-related damage (aim 3). The rationale for this work lies in the unmet need to improve rehabilitation strategies for ACL-injured patients. This proposal is conceptually and technically innovative as IT will: (1) utilize a non-invasive RAT model of ACL injury that preserves the native biological response, avoiding the limitations of traditional ACL transection models, (2) investigate the underexplored link between decreased neural activity, elevated ROS, and muscle atrophy as foundational evidence for future interventions, and (3) test the therapeutic potential of low-frequency nmes, a readily translatable intervention that avoids the limitations of high-frequency/high-force nmes while enhancing redox homeostasis. The goal of this preclinical research is to establish new strategies that could meaningfully enhance current and future ACL rehabilitation outcomes while equipping luke stoneback with the essential skills to promote his independent research program.
Transactions
| Action | Obligated | Date |
|---|---|---|
| Amendment | $0 | |
| Amendment | $44,424 | |
| Original award | $44,424 |
Quick answers
Who received award F31AR087153?
F31AR087153 was awarded to Regents Of The University Of Michigan by National Insititue of Arthritis and Musculoskeletal and Skin Diseases (National Institutes of Health) on December 1, 2026.
How much is award F31AR087153 worth?
$88,848 has been obligated on F31AR087153.
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