Project Grant F31AI203216
- The National Institute of Allergy and Infectious Diseases awarded Yale University $182,728 on February 6, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to optimize Wolbachia-based interventions for arboviral prevention. The project develops statistical and mathematical models to identify factors influencing the speed of Wolbachia introgression into wild Aedes aegypti populations and to determine optimal release timing and dosing strategies. Wolbachia is an...
- The National Institute of Allergy and Infectious Diseases awarded the Connecticut Agricultural Experimental Station $322,096 on February 5, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to identify biological drivers of Aedes aegypti vector competence for dengue, Zika, chikungunya, and yellow fever viruses. The research systematically evaluates the relative contributions of host genetics, viral genotype, and microbiome composition to vector competence variability...
- The National Institute of Allergy and Infectious Diseases awarded the University of California, San Diego $480,000 on September 16, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate the molecular basis for arboviral fitness in vector and reservoir hosts. The research examines how arboviruses replicate across evolutionarily distant hosts—insects and vertebrates—despite showing high specificity in their transmission cycles. Using alphaviruses as a...
- The National Institute of Allergy and Infectious Diseases awarded Yale University $242,958 on July 7, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate RNA structure probing approaches for understanding pro-inflammatory RNA helicases. The research applies chemical probing techniques—specifically co-transcriptional structure tracking (COSTSEQ) combined with DMS-MAPSEQ—to identify RNA substrates that DEAD-/DEAH-box helicases remodel and to map functional...
- The National Institute of Allergy and Infectious Diseases awarded Yale University $818,300 on August 1, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to develop modular degradation systems for extracellular proteins (MODES) as potential therapeutics for antibody-driven autoimmune disorders and heart failure. The research focuses on creating bifunctional small molecules designed to selectively remove disease-causing antibodies from circulation while preserving...
- The National Institute of Allergy and Infectious Diseases awarded Yale University $100,228 on October 9, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate the role of hookworm glycoproteins in parasite biology and disease pathogenesis. The research characterizes glycosylated antigens in human hookworm species and their roles in immunopathogenesis. The project will identify glycoproteins present throughout hookworm development in two species of human...
- The National Institute of Allergy and Infectious Diseases awarded Duke University $273,337 on September 1, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate the role of persistent sodium currents in modulating mosquito sensory behavior and spatial repellency to transfluthrin, a volatile pyrethroid insecticide. The research focuses on understanding how transfluthrin-based spatial emanators—recommended by the World Health Organization for malaria...
- Federal Project Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded $2.54M to the University of Texas Medical Branch at Galveston under the Allergy and Infectious Diseases Research program (CFDA 93.855) on September 8, 2025, for a four-year project period concluding August 31, 2029. This Project Grant supports investigator-initiated biomedical research examining the relationship between desiccation tolerance in Aedes aegypti mosquitoes and their...
- The National Institute of Allergy and Infectious Diseases awarded The University of Texas Southwestern Medical Center $249,000 on April 1, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to identify conserved antiviral host factors that restrict arbovirus replication across insect and mammalian hosts. The award funds development of an arbovirus rescue assay that screens viral immune evasion proteins (IEPs) encoded by mammalian viruses for their ability to sensitize...
- The National Institute of Allergy and Infectious Diseases awarded Yale University $632,078 on July 7, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate how industrial chemicals present in the cutaneous exposome can activate allergic responses through skin xenobiotic receptors. The project will identify mechanisms by which industrial compounds in contact with the skin license allergic inflammation in the intestine, building on prior findings that skin...
The National Institute of Allergy and Infectious Diseases awarded Yale University $100,228 on February 11, 2028, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to support research delineating barriers to the effectiveness of Wolbachia-based interventions for arboviral risk reduction. The research, conducted entirely in the United States and performed in Connecticut, investigates mechanisms driving inconsistent Wolbachia establishment in Aedes aegypti mosquitoes to optimize these interventions before wider implementation in U.S. areas at risk for dengue and other Aedes-borne diseases. The project leverages longitudinal datasets and samples from Wolbachia release programs in three Brazilian cities, including the NIAID-sponsored EVITA dengue cluster randomized controlled trial, to examine two critical determinants of intervention success. The first aim delineates meteorological and environmental factors influencing partial and complete Wolbachia loss by integrating field measurements with molecular markers to develop statistical and mathematical models characterizing patterns and drivers of loss. The second aim uses whole-genome sequencing data to determine how fine-scale Aedes aegypti population structure influences Wolbachia introgression dynamics following releases. The award period of performance runs from February 11, 2028, through August 15, 2028.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $50.1k | 8/11/26 | ||
| Not listed | $0 | 8/11/26 |