Project Grant F31AI200402
- Federal Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), awarded The Scripps Research Institute a $1.62M Project Grant (awarded July 20, 2026; completion June 30, 2031) to develop novel antiviral therapeutics targeting mammarenaviruses. The research focuses on characterizing the mechanisms of action and broad-spectrum efficacy of two lead compound inhibitors—MCOT466 and MCPB916—that...
- Federal Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded Scripps Research Institute a $506,000 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) on July 9, 2025, with a completion date of June 30, 2027. The award supports the development of high-throughput technologies for generating and screening small interfering RNA (siRNA)-peptide conjugates designed to improve delivery efficiency for viral infection...
- Federal Project Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded Scripps Research Institute a Project Grant totaling $511,531 on February 13, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855). The award, with a completion date of January 31, 2031, supports the development and characterization of HIV vaccine candidates utilizing a lipid nanodisc platform. The project delivers biophysical and structural analysis services...
- Federal Project Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded The Scripps Research Institute a Project Grant totaling $270,443 under the Allergy and Infectious Diseases Research program (CFDA 93.855), with an award date of June 23, 2026, and completion date of May 31, 2028. This research initiative focuses on characterizing host-specific profiles of defective viral genomes (DVGs) in influenza virus, with particular emphasis on understanding how...
- Federal Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded Scripps Research Institute $899,741 on April 1, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to develop a long-acting injectable (LAI) therapy for hepatitis B virus (HBV) treatment in individuals co-infected with human immunodeficiency virus (HIV). This five-year project, scheduled for completion March 31, 2031, addresses a critical health need for approximately...
- Federal Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded Scripps Research Institute a $552,000 Project Grant on July 16, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to conduct basic immunological research on long-lived plasma cells (LLPCs). The research project, which extends through June 30, 2031, focuses on understanding the mechanisms that govern plasma cell longevity and survival beyond their primary function...
- Federal Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded Scripps Research Institute a Project Grant of $931,385 under the Allergy and Infectious Diseases Research program (CFDA 93.855) on June 10, 2026, with a completion date of May 31, 2027. The award supports research and development of glycoengineered HIV-1 envelope vaccine immunogens designed to enhance neutralizing antibody responses. The primary deliverable involves producing core...
- Federal Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded The Scripps Research Institute a $919,605 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) effective June 10, 2026, with a completion date of May 31, 2031. This award supports antibody-guided vaccine development research targeting human astrovirus (HAstV), a leading cause of viral diarrhea in children and a significant public health concern affecting...
- Federal Project Grant Award Summary The Scripps Research Institute received a $1,379,954 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), effective August 21, 2025, with completion targeted for July 31, 2030. The award supports systematic research to engineer durable immunity through optimization of Human Immunodeficiency Virus (HIV) vaccine parameters designed to drive...
- Federal Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded Scripps Research Institute a $897,277 Project Grant (CFDA 93.855 - Allergy and Infectious Diseases Research) on June 25, 2026, for research titled "Structural and Functional Insights into Monkeypox Entry and Neutralization." The five-year project, extending through May 31, 2031, will deliver research outputs focused on identifying primary targets of neutralizing antibodies against...
Federal Project Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded Scripps Research Institute a Project Grant of $111,342 (Award Date: December 8, 2026; Completion Date: June 14, 2028) under the Allergy and Infectious Diseases Research program (CFDA 93.855) to conduct research on mammarenavirus host-factor interactions. The research will deliver a comprehensive landscape of host-virus interactions supporting Lassa virus (LASV) replication, transcription, and translation. This knowledge will identify novel druggable targets to support the future development of host-directed antivirals for Lassa fever treatment. The project comprises two primary research aims. Under Aim 1, researchers will conduct a genome-wide CRISPR/Cas9 screen in HEK293T cells expressing a functional LASV ribonucleoprotein complex to identify host factors contributing to viral genome replication and transcription. Under Aim 2, investigators will examine how mammarenaviruses engage and modulate the host translation machinery to promote viral gene expression. These research deliverables address a critical public health need, as no FDA-approved vaccines or effective antivirals currently exist for Lassa fever, a hemorrhagic fever disease endemic to Western Africa with significant morbidity and mortality rates.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $0 | 7/14/26 | ||
| Not listed | $0 | 6/9/26 | ||
| Not listed | $37.1k | 6/9/26 | ||
| Not listed | $37.1k | 6/9/26 | ||
| Not listed | $37.1k | 6/9/26 |