Understanding rnase l deactivation and promotion of cellular immunity
Active Project Grant Awarded Last action
- Award ID
- F31AI200225
- Recipient
-
University Of Florida UEI NNFQH1JAPEP3
- Awarding agency
-
National Institute of Allergy and Infectious Diseases
National Institutes of Health, Department of Health and Human Services
- Obligated
- $74,228
Award facts
- Assistance listing
- 93.855 Allergy and Infectious Diseases Research
- Completion date 0% complete
- Originally
- Place of performance
- Jupiter, FL 33458, USA
Award details come from USAspending.gov.
Description
- Abstract
- Ribonuclease l (rnase l) is a key antiviral enzyme that degrades host and viral mrna in response to viral infection. Dysregulation of rnase l is implicated in viral pathogenesis, cancer, and immune disorders, yet if cells resolve this activation and how rnase l shapes adaptive immunity remains poorly understood. My preliminary data indicate that cells can recover from rnase l activation and that IT promotes cellular immunity. Thus, rnase l activation is non-terminal and enhances immune cell-mediated clearance of infected cells. My overarching hypothesis is that rnase l-promotes apoptosis by enhancing immune cell-mediated targeting. I will test this hypothesis through two central aims: (1) identify the mechanisms and consequences of rnase l deactivation. (2) identify how rnase l promotes immune cell-mediate apoptosis. These studies will define a novel mechanism by which rnase l bridges innate and adaptive immunity. Furthermore, my findings may inform treatments for long-term inflammation and uncover new immune-modulating therapies. In parallel, i will receive training in immunology, RNA biology, and quantitative proteomics under the guidance of an interdisciplinary mentorship team at scripps research, preparing me for a career at the intersection of RNA biology and immune regulation.
Transactions
| Action | Obligated | Date |
|---|---|---|
| Amendment | $37,114 | |
| Amendment | $0 | |
| Original award | $37,114 |
Quick answers
Who received award F31AI200225?
F31AI200225 was awarded to University Of Florida by National Institute of Allergy and Infectious Diseases (National Institutes of Health) on November 19, 2026.
How much is award F31AI200225 worth?
$74,228 has been obligated on F31AI200225.
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