Identification of the genetic mechanisms involved in modulating artemisinin tolerance under oxidative stress in p. Falciparum
Active Project Grant Awarded Last action
- Award ID
- F31AI200144
- Recipient
-
University Of South Florida UEI NKAZLXLL7Z91
- Awarding agency
-
National Institute of Allergy and Infectious Diseases
National Institutes of Health, Department of Health and Human Services
- Obligated
- $82,204
Award facts
- Assistance listing
- 93.855 Allergy and Infectious Diseases Research
- Completion date 0% complete
- Originally
- Place of performance
- Tampa, FL 33612, USA
Award details come from USAspending.gov.
Description
- Abstract
- Malaria continues to pose a major global health burden, with over 250 million infections and nearly 600,000 deaths reported in 2024 according to the world health organization. The deadliest form of the disease is caused by plasmodium falciparum. In malaria-endemic regions such as sub-saharan africa, widespread hemoglobinopathies like sickle cell trait create pro-oxidative environments in red blood cells, restricting parasite growth. Artemisinins, which are the cornerstone of malaria treatment, also exert their antimalarial activity through potent oxidative stress. Although malaria-endemic areas coincide with regions of high artemisinin use and sickle cell trait frequency, the influence of oxidative stress from hemoglobinopathies on parasite-drug interactions is not clearly understood. Recent data suggests that oxidative stress microenvironment of sickle trait cells confers artemisinin tolerance. Elucidating how parasites adapt to oxidative stress is essential for combating the emergence of artemisinin tolerance and preserving drug efficacy. This project supports niaid's mission by investigating the host-pathogen-drug interface in p. Falciparum and identifying key parasite survival pathways relevant to malaria pathogenesis and treatment. The long-term objective is to define the molecular mechanisms by which p. Falciparum tolerates oxidative stress and develops artemisinin tolerance. The central hypothesis is that oxidative stress environments activate adaptive gene expression and metabolic responses regulated in part by epigenetic mechanisms. The research approach integrates p. Falciparum culture and drug sensitivity assays with functional genomics, transcriptomic profiling, and epigenetic analysis. The outcomes of this project will provide mechanistic insight into parasite adaptation in adverse conditions and contribute to developing more effective strategies for malaria treatment, especially in populations with high rates of hemoglobinopathies. These findings are directly aligned with niaid's commitment to addressing infectious diseases that disproportionately impact global health.
Transactions
| Action | Obligated | Date |
|---|---|---|
| Amendment | $41,102 | |
| Amendment | $41,102 | |
| Original award | $0 |
Quick answers
Who received award F31AI200144?
F31AI200144 was awarded to University Of South Florida by National Institute of Allergy and Infectious Diseases (National Institutes of Health) on November 23, 2026.
How much is award F31AI200144 worth?
$82,204 has been obligated on F31AI200144.
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