Determining the mechanism of cell death of small molecules produced by pseudomonas aeruginosa against acanthamoeba castellanii

Active Project Grant Awarded Last action

Award ID
F31AI181569
Recipient
Awarding agency
Obligated
$166,860

Award facts

Assistance listing
93.855 Allergy and Infectious Diseases Research
Completion date 70% complete
Place of performance
New Haven, CT 06519, USA

Award details come from USAspending.gov.

Description

As the agency reported it.

Abstract
Acanthamoeba castellanii is a free-living amoeba (FLA) that causes usually fatal central nervous system infections like granulomatous amebic encephalitis. Flas like a. Castellanii are bacterivorous and CO-exist with pseudomonas aeruginosa. P. Aeruginosa are ubiquitous environmental gram-negative bacteria. Given that a. Castellanii creates an evolutionary pressure for p. Aeruginosa to defend itself against amoebal grazing, we hypothesized that p. Aeruginosa may produce one or more secreted amoebicidal compounds that can be harnessed to treat amoeba infections in humans. We have since demonstrated that the cell-free supernatants of p. Aeruginosa strain PA14 are lethal to a. Castellanii trophozoites. Our preliminary data has established that trophocidal activity resides in a

Transactions

Action Obligated Date
Amendment $0
Amendment $34,456
Amendment $34,456
Amendment $48,974
Amendment $48,974
Original award $0

Quick answers

Who received award F31AI181569?

F31AI181569 was awarded to Yale Univ by National Institute of Allergy and Infectious Diseases (National Institutes of Health) on January 10, 2025.

How much is award F31AI181569 worth?

$166,860 has been obligated on F31AI181569.

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