Project Grant F30CA287690

Award Date 12/25/24
Completion Date 7/14/26
Dollars Obligated $162K
Federal Grant Program
93.398
Assistance Type
Project Grant
Place of Performance
New York, NY 10029, USA
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The key objectives are to: 1) Examine how knocking out the SOCS1 gene, a negative regulator of the IFNγ pathway, affects the tumor immune composition and response to immune checkpoint blockade therapy in mouse models and human lung cancer samples, and 2) Systematically knock out all 162 interferon-stimulated genes (ISGs) to determine how each impacts tumor immunity and the tumor microenvironment. These studies aim to provide a more nuanced understanding of the IFNγ pathway's paradoxical effects on tumor immunity and identify specific ISGs that could be targeted to enhance immunotherapy responses in lung cancer.

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