Development and evaluation of neuroimaging biomarkers of structural and functional network degeneration in alzheimer's disease
Active Project Grant Awarded Last action
- Award ID
- F30AG087698
- Recipient
-
The University Of Texas Health Science Center At San Antonio UEI C3KXNLTAAY98
- Awarding agency
-
National Institute on Aging
National Institutes of Health, Department of Health and Human Services
- Obligated
- $209,624
Award facts
- Assistance listing
- 93.866 Aging Research
- Completion date 43% complete
- Place of performance
- San Antonio, TX 78229, USA
Award details come from USAspending.gov.
Description
- Abstract
- The amyloid-TAU-neurodegeneration (a/t/n) biomarker framework for alzheimer's disease (ad) indicates binary (presence/absence) designations for each type of pathology. However, the anatomical information provided by imaging modalities, particularly in assessment of neurodegeneration "n", is not currently incorporated into this framework. Further, preliminary data strongly suggests a dissociation between structural and functional brain alterations in ad, a phenomenon likely reflective of underlying pathophysiology and not yet explored in the literature. There is a clear opportunity for extending the ATN biomarker framework by incorporation of spatially- defined neuroimaging biomarkers. A robust, validated approach for neuroimaging biomarker development uses meta-analysis to define a node-and-edge model followed by validation in primary resting-state fmri data. This was recently successfully applied to multiple sclerosis, with upcoming clinical trials planned. The current proposal utilizes a similar approach, with three aims: 1) to develop a meta-analytic node-and-edge model of structural changes in ad; 2) to develop a meta-analytic node-and-edge model of functional changes in ad; 3) to determine the ability of the models developed in aims 1 & 2 to detect clinical (healthy à mild cognitive impairment ÀAD) and pathological (healthy à a+ à a+t+ à a+t+n+) progression of ad. Aim 3 will utilize primary resting-state fmri data from the alzheimer's disease neuroimaging initiative. Directly, completion of the proposed aims will provide characterization of the dissociation of structural and functional changes in ad (aims 1 & 2) and a spatially- based functional connectivity imaging biomarker for disease progression along the ad continuum (aim 3). Longitudinally, knowledge gained from the proposed project will advance the understanding of ad pathophysiology, allowing for development of targeted therapeutics, and ultimately decreasing morbidity and mortality from neurodegenerative diseases.
Transactions
| Action | Obligated | Date |
|---|---|---|
| Amendment | $40,452 | |
| Amendment | $564 | |
| Amendment | $564 | |
| Amendment | $0 | |
| Amendment | $0 | |
| Amendment | $0 | |
| Amendment | $42,011 | |
| Amendment | $42,011 | |
| Amendment | $42,011 | |
| Original award | $42,011 |
Quick answers
Who received award F30AG087698?
F30AG087698 was awarded to The University Of Texas Health Science Center At San Antonio by National Institute on Aging (National Institutes of Health) on June 9, 2025.
How much is award F30AG087698 worth?
$209,624 has been obligated on F30AG087698.
On GovTribe
See this award's full record
- Every transaction and subaward
- The recipient's other awards and teaming partners
- Similar grant awards
- Ask GovTribe AI about this award