Project Grant EH26716519

The National Institute of Mental Health (NIMH) awarded a $679,118 Project Grant (CFDA 93.242 - Mental Health Research Grants) to the University of California, Santa Cruz (UCSC) to study the cellular and circuit mechanisms underlying the long-lasting therapeutic effects of the psychedelic drug psilocybin in the stressed brain. The project aims to determine how psilocybin affects synaptic plasticity, cortical functional networks, and the representation of behavioral variables in the stressed...

This Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), provides $389,735 to New York University (NYU) to research the neural correlates of mental simulation in multi-step planning. The overarching goal is to obtain a unified understanding of the brain mechanisms underlying complex planning by combining functional MRI, magnetoencephalography, eye-tracking, and computational modeling approaches. The key...

This four-year, $400,000 Project Grant from the National Science Foundation's Division of Information and Intelligent Systems supports research at the Massachusetts Institute of Technology under the Computer and Information Science and Engineering program. The grant funds the development of new techniques for composing implicit representations to enable machines to perceive and reconstruct 3D scenes in a more generalizable manner. Investigators will explore methods to make representations...

This federal Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), provides $314,113 to Physical Sciences Inc. (PSI) to develop and demonstrate a high-speed, multicolor confocal fluorescence imager. The goal is to create a tool that can simultaneously capture multi-wavelength signals and display separated or merged multicolor images and 3D stacks at over 140 Hz frame rate. This advanced imaging system will be...

This $305,002 Project Grant, awarded by the National Science Foundation's (NSF) Computer and Information Science and Engineering (CISE) program (CFDA 47.070), aims to develop novel approaches to mitigate hallucinations in large-scale multimodal learning models (LMMs). The key products and services to be delivered under this 5-year award include: New learning methods to address imbalanced data that causes hallucinations in LMMs. Novel shuffling learning approaches to address misalignment across...

This Project Grant award, funded by the National Eye Institute (NEI) under the Vision Research program (CFDA 93.867), supports research to investigate how the hippocampus and primary visual cortex interact to generate coordinated mental simulations during active behavior. The $124,205 award, effective from March 1, 2025 to February 28, 2027, is being provided to the University of California, San Francisco (UCSF) to conduct this research. The proposed work aims to provide key insights into the...

This federal Project Grant award, identified as R21DA062252, was provided by the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279). The $246,000 award will fund a research project to investigate the brain mechanisms underlying the therapeutic potential of psilocybin, a psychoactive compound, for the treatment of mental health conditions such as anxiety, depression, addiction, and illness-related distress. The research aims to identify the...

The National Institute of Mental Health (NIMH) awarded a $2,295,419 Project Grant (CFDA 93.242 - Mental Health Research Grants) to Yale University to conduct a clinical trial of a Mindfulness-Based Neurofeedback (MBNF) intervention used to augment Dialectical Behavior Therapy (DBT) skills group training in adults with Borderline Personality Disorder (BPD). The study aims to strengthen the ability of subjects to practice mindfulness effectively and amplify the therapeutic benefits of DBT skills...

This Project Grant award from the National Institute of Biomedical Imaging and Bioengineering (NIBIB), under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286), is for the development of bioresorbable microdevices that can deliver intermittent sub-perceptual doses of 5HT2A agonists, such as psilocybin, to mitigate depression associated with opioid use disorder (OUD). The $306,556 award will fund the development of tailored drug...

The National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), awarded a $505,311 Project Grant to Intelligent Imaging Innovations, Inc. (3i) to establish the feasibility of combining advanced optical techniques for large-scale, all-optical electrophysiology. The goal is to develop a commercial instrument that can simultaneously record from thousands of neurons and selectively activate optogenetically-labeled neurons across multiple brain...