Project Grant DP5OD039470
- This federal Project Grant award for $243,950.00 was provided by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846). The award supports a series of research aims to develop prognostic models for predicting the long-term course of atopic dermatitis (persistent disease and comorbidities) in diverse global settings, including cohorts from Uganda, Ecuador, and the United Kingdom....
- This federal Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), provides $343,904 to The Regents of the University of California, San Francisco to investigate transcriptional abnormalities in skin-resident T cells as potential biomarkers for atopic dermatitis in Asian and Hispanic genetic backgrounds. The research aims to validate an abnormal atopic T...
- This Project Grant award, provided by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), aims to define and treat genetic abnormalities in overlapping rashes of psoriasis and atopic dermatitis (termed "PSO-AD"). The $628,968 award to the University of California, San Francisco will leverage innovative biomarker techniques, including spatial transcriptomics and...
- This federal Project Grant award of $716,281 from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) supports research to investigate the mechanisms by which T regulatory cells control allergic skin inflammation in atopic dermatitis. The research aims to use the DOCK8 deficiency model to study the pathways that drive atopic dermatitis independently of skin barrier defects and determine the mechanisms by which...
- This federal Project Grant award, valued at $1, was provided by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121). The funding will support research to analyze cancer-specific molecular rhythmicity in pancreatic ductal adenocarcinoma (PDA) using publicly available datasets. The project aims to identify potential druggable targets for chronotherapy in PDA, leveraging various biomedical research databases. The...
- This federal Project Grant award of $528,558.00 was provided by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research federal grant program (CFDA 93.846). The goal of the research project is to study the immune system mechanisms underlying treatment resistance and paradoxical inflammatory side effects in patients with atopic dermatitis who receive the antibody therapy dupilumab. The research will...
- The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $432,209 Project Grant under the Oral Diseases and Disorders Research (CFDA 93.121) program to the University of California, Los Angeles (UCLA) for a 2-year period starting on August 1, 2023. The funding supports research to investigate the role of the CXCL10-CXCR3 axis in the compounding effects of diabetes mellitus on periodontitis. Specifically, the research aims to further elucidate the role of CXCL10 in the...
- This federal Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), provides $995,000.00 to the ADA Forsyth Institute, Inc. (doing business as The Forsyth Institute) to conduct research on the mechanisms of peroxisome proliferator-activated receptor-alpha (PPAR-α) regulation in periodontitis. The research aims to determine if PPAR-α agonist treatment can modulate macrophage polarization to...
- The federal Project Grant award of $309,038, issued on August 8, 2025 by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121), supports the development of a novel anti-infective therapy for treating periodontitis. The project aims to develop a first-in-class inhibitor of the "red complex" bacteria (P. gingivalis, T. forsythia, and T. denticola) that are considered the causative agents of periodontitis, a...
- This $442,750 Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121) will fund a research project titled "A Pathomimetic Gingiva-on-a-Chip for Assessing Microbiota-Directed Anti-Inflammatory Therapeutics" at the Cleveland Clinic Lerner College of Medicine of Case Western Reserve University. The project aims to identify metabolites that can selectively enhance beneficial oral...
This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research federal grant program (CFDA 93.121), aims to advance the treatment of atopic dermatitis (AD) by identifying novel drug targets. The $1 award, provided to the University of California, San Diego, will develop an innovative chemical biology platform called PACE (Profiling of Active Cutaneous Enzymes) in conjunction with untargeted lipidomics. This research seeks to identify dysregulated enzymes and lipid alterations in human AD skin, validate the functional impact of these targets in preclinical models, and screen for selective inhibitors to develop new therapeutic strategies for AD. The expected outcomes include enhanced understanding of the role of lipids and enzymes in skin health and disease, as well as the potential identification of novel drug targets applicable to other cutaneous disorders.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $1 | 8/11/25 |