Project Grant DP5OD039379
- The University of Pennsylvania was awarded a $174,420 Project Grant by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research federal grant program (CFDA 93.846). The grant, awarded on May 1, 2025, will support research led by Dr. Leo Wang to develop hydrogel-based therapies for treating alopecia areata, a common autoimmune skin disease that causes hair loss. The project will leverage the specialized...
- The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $685,594 Project Grant under the Oral Diseases and Disorders Research (CFDA 93.121) program to The Pennsylvania State University (Penn State) to support research on leveraging microsurgery and bioprinting to enable rapidly vascularized tissue engineering for craniomaxillofacial (CMF) injury reconstruction. The project aims to advance a novel microsurgical "vascular micropuncture" technique to enhance the...
- This federal Project Grant award of $588,952 from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), is funding research to develop a bio-inspired scaffold (PerióPatch) for regenerating Sharpey's fibers and the periodontal ligament (PDL). The research aims to integrate biophysical and biochemical cues into a matrix to guide PDL stem cell migration, growth, and the formation of well-aligned PDL principal and...
- The National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research federal grant program (CFDA 93.121), awarded a $913,000 Project Grant to the University of Southern California to support research on periodontal regeneration using supramolecular nanomaterials. The project aims to identify biologically active peptides, specifically the leucine-rich amelogenin peptide (LRAP), that can stimulate the differentiation of periodontal ligament cells...
- The National Institute of General Medical Sciences (NIGMS), through its Biomedical Research and Research Training program (CFDA 93.859), awarded a $349,892 project grant to Fesariustherapeutics Inc. to develop Dermisphere Shield, an antimicrobial dermal regeneration template for application in challenging wound environments. The project aims to create a dermal regeneration scaffold that promotes rapid cellular infiltration, angiogenesis, and accelerated wound healing, potentially offering...
- This $428,600 federal Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), supports an investigation into how RNA-directed feedback loops coordinate wound healing and regeneration. The research project aims to understand the conserved developmental pathways and heterochronic genes that regulate cell migration, fate, and timing during normal adult wound repair and regeneration,...
- This Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) provides $355,938 to Yale University to study the signaling dynamics that coordinate stem cell behaviors during tissue regeneration. The research aims to define the dynamics of epithelial ERK and mesenchymal TGFβ signaling and assess their functional impact on regenerative processes in the hair...
- This $367,577 Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research) to Adepthera LLC aims to develop a regenerative peptide therapy to accelerate pressure ulcer healing. Specifically, the award will fund research to identify an optimal formulation of a self-assembling adrenomedullin (ADM) analog gel that can improve local blood circulation and wound healing in aging and diabetic mouse models. The proposed therapy would be administered weekly or biweekly via...
- This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) aims to develop a hyperstable and bioactive FGF1-FGF2 dimer formulation for effective healing of diabetic skin wounds. The $435,226 award to the University of Arkansas will fund research activities across three key objectives: Designing a hyperstable and bioactive FGF1-FGF2 dimer and its variants, Developing injectable anionic...
- This $224,100 federal Project Grant award, funded by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), will support research to identify epigenetic factors that control the longevity of epidermal stem cells in adult skin. The project aims to elucidate the functional role of epigenetic regulators and their corresponding histone modifications in maintaining the longevity of hair...
The University of Pennsylvania was awarded a Project Grant by the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), to develop a multicomponent hydrogel system that can spatiotemporally activate Wnt and Sonic Hedgehog signaling pathways to promote hair follicle neogenesis and scarless wound healing. The $1 project grant was awarded on Aug 6, 2025 and is scheduled for completion by Jul 31, 2030. The proposed research aims to engineer a two-component hydrogel that can release specific agonists to sequentially activate key signaling pathways and regenerate hair follicles, which can then prevent and treat fibrotic scarring in human skin wounds. This research will be conducted in the Department of Dermatology at the University of Pennsylvania, a top-ranked institution for NIH funding with strong research infrastructure and collaborations across the university.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $1 | 8/5/25 |