This Project Grant award, funded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), aims to advance the field of native mass spectrometry (MS) analysis. The $316,825 award, effective May 1, 2025 through April 30, 2026, supports the development of an innovative intact mass deconvolution method designed to improve the speed, accuracy, and user-friendliness of proteins and nucleic acid molecular weight...
This Project Grant award of $532,947 from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) will fund the development and validation of a unified, cloud-based data processing workflow and database called LC-BINBASE for high-resolution LC-MS/MS metabolomics and lipidomics data. The goal is to create a standardized and reproducible metabolomics data processing system that can be used across different laboratories and mass...
This $737,124 Project Grant award from the National Institute of General Medical Sciences (CFDA 93.859 Biomedical Research and Research Training Program) will enable The Trustees of the University of Pennsylvania to acquire a Thermo Scientific Orbitrap IQ-X Tribrid mass spectrometer coupled to a Vanquish dual column liquid chromatography system. This highly sensitive instrumentation will be used to expand the Translational Biomarker Core's lipidomics, metabolomics, isotope tracing, and...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) provides $350,000 to Sinopia Biosciences Inc. to develop computational methods for predicting the metabolomic profiles of unscreened chemical compounds. The goal is to enable more efficient metabolomics-based drug discovery by combining sparse experimental screening with computational inference. Key objectives include: 1) developing methods to...
This $306,872 Project Grant awarded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports the development of a commercial prototype for Fluid Discovery, Inc.'s "Universal Platform for Ultrahigh-Throughput Biocatalyst Evolution with Micro-Mass Spectrometry." This transformative screening platform combines scalable hardware, label-free mass spectrometry, and advanced computational techniques to...
This federal Project Grant award, valued at $476,385.00 and funded by the National Science Foundation's (NSF) Division of Chemistry, supports a collaborative research project between Professor Michael Marty's team at the University of Arizona and industrial partners at Genentech, Inc. The project aims to develop new computational algorithms and experimental methods for improved analysis of complex mass spectrometry data, particularly focused on enabling more widespread use of intact mass...
The National Institute of General Medical Sciences (NIGMS) has awarded a $492,000 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to Princeton University. The grant, which runs from Sep 1, 2024 to Aug 31, 2029, supports research aimed at accessing previously hidden sources of microbial natural products and investigating their structures, functions, therapeutic uses, and biosynthetic pathways. Key objectives include eliciting cryptic metabolites from...
This $248,893 Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) aims to develop a data-driven approach to automatically identify and analyze the impact of biomedical tools, methods, and software (collectively called BioTools) used in scientific research. The key products and services to be delivered under this 4-year grant include: Creating a ground-truth corpus by extracting laboratory...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) supports the development of efficient and accurate methods for identifying novel natural product small molecules from complex mass spectral datasets. The $275,484 award, which began on Sep 1, 2023 and runs through Aug 31, 2024, will enable the grantee, Chemia Biosciences, Inc., to integrate genome mining with computational metabolomics to...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $314,363 to Delineate Inc. to develop an innovative platform that uses large language models (LLMs) to accelerate the building and repurposing of quantitative systems pharmacology (QSP) models from scientific literature. The key objectives are to: (1) develop an LLM-powered platform for efficient QSP model construction...
This Project Grant award from the National Institutes of Health (NIH) Office of the Director under the Trans-NIH Research Support program (CFDA 93.310) will fund the development of two computational tools to advance mass spectrometry-based metabolomics research.
The first tool, DecipherMS, will use large language models to enable de novo annotation of both known and unknown chemical structures from mass spectrometry data, addressing a critical gap in existing computational tools for metabolomics. The second tool, FoundationMS, will standardize data preprocessing workflows through self-supervised learning on a repository-scale corpus of metabolomic data.
The total funding for this 5-year project is $391,851, with an award date of September 19, 2024. The work will be conducted by the Trustees of Princeton University, a prominent private research institution.