This Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), is focused on leveraging electronic health records (EHRs) and genetic data to develop predictive models and identify subtypes of psychosis-related disorders. The key products and services to be delivered under this $1,424,534 award include: Building machine learning-based prediction models to forecast clinical outcomes such as treatment response, illness...
This Project Grant award from the National Institute of Mental Health (NIMH), under CFDA 93.242 Mental Health Research Grants, is for a collaborative research project titled "PSYCHEMERGE: ADVANCING PRECISION PSYCHIATRY." The $984,036 award will be used to extend the foundational efforts of the PSYCHEMERGE network to address barriers to scalability, utility of genomic data, clinical application, and translation to clinical practice in a precision psychiatry paradigm. The key aims of the...
This Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), is focused on understanding the neural mechanisms underlying psychiatric comorbidities across posttraumatic stress disorder (PTSD), major depressive disorder (MDD), and anxiety disorders (ANXs). The $769,753 award will leverage large-scale multimodal neuroimaging datasets from ENIGMA and UK Biobank to identify neural biomarkers and biotypes that can help...
This federal Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), provides $714,615 to New York University School of Medicine to conduct research on dissecting the role of non-coding repeats in the genetics of psychiatric disorders like schizophrenia and bipolar disorder. The key objectives are to: Fine map regulatory features of a repeat expansion within the CACNA1C gene, which has been strongly associated with...
The National Institute of Mental Health (NIMH) awarded a $422,280 Project Grant under the Mental Health Research Grants program (CFDA 93.242) to the University of Colorado-Denver. The 2-year grant, running from April 1, 2025 to March 31, 2027, will support research to identify and interrogate novel intracellular proteins that underlie the distinct nanoscopic architecture of the synaptic adhesion molecules neurexin-1 and neurexin-3. Specifically, the research will use advanced imaging...
This Project Grant award from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) provides $961,668 to The Feinstein Institutes for Medical Research to leverage electronic health records, dimensional phenotyping, and genetic analyses to build predictive models and identify subtypes of clinical outcomes for individuals with schizophrenia and other psychosis-related disorders. The 5-year project aims to advance precision psychiatry by...
The National Institute of Mental Health (NIMH) awarded a $904,100 Project Grant under the Mental Health Research Grants program (CFDA 93.242) to the Lovelace Biomedical Research Institute in Albuquerque, New Mexico. The grant, awarded on May 5, 2025, will fund a longitudinal study to develop algorithms that predict mental health functioning and related outcomes, such as recidivism and substance use relapse, in incarcerated women. The research will utilize multimodal data, including psychosocial,...
This Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), will provide $3,085,041 to the University of Pittsburgh to conduct longitudinal research on adolescent brain maturation and its relationship to psychopathology. The research aims to: Characterize the longitudinal trajectory of neuropil growth/contraction using 3D whole-brain phosphorus magnetic resonance spectroscopy (31P MRS). Elucidate the relationship...
This Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), aims to develop a novel data-driven approach to identify sex-specific biological subtypes (biotypes) of psychotic disorders. The $525,048 award to Georgia State University Research Foundation Inc., effective December 13, 2024, will fund a 4-year research project with the following key objectives: Apply unsupervised and supervised machine learning methods to...
The National Institute of Mental Health (NIMH) awarded a $1,613,367 Project Grant under the Mental Health Research Grants (CFDA 93.242) program to Geisinger Clinic in Danville, PA. The grant, titled "7/7-PSYCHEMERGE: ADVANCING PRECISION PSYCHIATRY", aims to address barriers to scalability, utility of genomic data, clinical application, and translation to clinical practice in a precision psychiatry paradigm. Specifically, the grant will create a nationwide federated transfer-learning...
This $1,413,000 Project Grant award from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) will fund research at Arizona State University (ASU) to develop a new model for identifying biocomposite clusters of stress-related psychiatric disorders (SRPDs). The key objectives are to: 1) identify epigenetic sites and brain regions most responsive to environmental factors, 2) identify genetic and endophenotype clusters that mediate the relationship between adverse childhood experiences and SRPD symptoms, and 3) validate this model in a separate clinical cohort. This transdisciplinary project integrates psychiatry, genomics, neuroscience, and advanced computational approaches to address the biological complexity of SRPDs. The award period runs from Sep 2024 to Aug 2027.