The National Institutes of Health (NIH) is providing a $1,345,424 project grant under the Trans-NIH Research Support program (CFDA 93.310) to the Regents of the University of Michigan for the development of a "temporally scalable recording of brain-wide single-cell physiology" technology. The project aims to create a genetically-encoded "protein ticker tape" system that can record and store long-term (up to 1 year) physiological data, including gene expression and signaling activities, in individual brain cells across the entire mouse brain. This novel recording approach is intended to enable transformative research on neuroscience and neurological disorders by providing unprecedented spatial and temporal insights into brain function. The award period runs from Sep 10, 2024 to Sep 9, 2027, with the University of Michigan as the primary grantee.