Project Grant DP2MH132943

Award Date 9/1/22
Completion Date 8/31/25
Dollars Obligated $3.5M
Federal Grant Program
93.242
Assistance Type
Project Grant
Place of Performance
New York, USA
Similar Awards
This $1,426,134 Project Grant awarded by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants (CFDA 93.242) program aims to study the role of the TREM2 receptor on microglia in mediating the hippocampal synaptic and cognitive deficits observed in mouse models of early life neglect and deprivation. The research will test whether overexpression of TREM2 can correct the synaptic and cognitive abnormalities seen in adolescent mice exposed to impoverished rearing...
The National Institute of Mental Health (NIMH) awarded a $4,925,302 Project Grant under the Mental Health Research Grants program (CFDA 93.242) to The Washington University to conduct systematic and scalable phenotyping of over 100 mouse mutants for neuropsychiatric disease genetics. The project, which runs from December 1, 2024 to November 30, 2029, will use behavioral analysis, anatomical mapping, and molecular assessments to investigate the impact of prioritized mutations associated with...
This $489,500 Project Grant, awarded by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, will support a collaborative research initiative at Boston Children's Hospital to elucidate how human microglia-like cells leverage mRNA translational control mechanisms to respond to environmental cues. The research aims to define the translational landscape...
This Project Grant award from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) provides $165,796 to the University of California, Los Angeles (UCLA) to conduct research on the impact of autism spectrum disorder (ASD) genetic risk on microglia-neuronal interactions. The research aims to leverage human stem cell culture and 3D human cortical spheroid models to assess how ASD genetic risk factors, including mutations in the CHD8 and...
This Project Grant award of $742,484 from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants (CFDA 93.242) program will fund research to characterize a genetic mouse model and delineate its function in the brain. The award to the University of Alabama at Birmingham will span 5 years from January 2025 to October 2029. The research aims to identify novel downstream targets in the mammalian brain, elucidate behavioral outcome measures, and generate new hypotheses...
This Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), is providing $610,784 to Emory University to conduct comprehensive research on the role of neuroinflammation in 22q11.2 Deletion Syndrome (22QDS). The research aims to assess the impact of 22QDS on microglial function using patient-derived induced pluripotent stem cell (iPSC) models, determine the molecular and cellular effects of 22q11.2 deletions on...
The National Institute of Mental Health (NIMH) awarded a $314,113 Project Grant under the Mental Health Research Grants program (CFDA 93.242) to Physical Sciences Inc. (PSI) of Andover, MA. The grant will fund the development and demonstration of a high-speed, multicolor confocal fluorescence imager to simultaneously capture multi-wavelength signals and display them as separated or merged multicolor images and 3-D stacks. This technology innovation will enable mapping of complex neuronal network...
This $475,369 federal Project Grant awarded by the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, supports research to better understand how microglia (the brain's resident macrophages) are programmed by the brain environment following transplantation. The primary awardee, The Trustees of the University of Pennsylvania, will use single-cell RNA and ATAC sequencing to...
The National Institute of Mental Health (NIMH) awarded a $245,475 Project Grant (CFDA 93.242 - Mental Health Research Grants) to The General Hospital Corporation, doing business as Massachusetts General Hospital (MGH), to conduct research on defining the neuro-immune and placental profile of a dual-hit Toll-Like Receptor 7 (TLR7) and stressor mouse model. The key objectives of this 2-year research project are to determine whether prenatal TLR7 stimulation induces maternal, placental, and...
This federal Project Grant award of $414,650.00 from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) supports research on the molecular mechanisms regulating the pace of silent synapse maturation and its impact on neural network refinement in the visual cortex. The project, titled "Mechanisms of Silent Synapse Maturation for Excitatory Network Refinement," aims to uncover signaling pathways that govern the balance between...

This three-year, $3.456 million project grant from the National Institute of Mental Health (NIMH) Mental Health Research Grants program (CFDA 93.242) will fund research into the role of microglia in neurodevelopmental disorders. The grantee, Cold Spring Harbor Laboratory, will merge two-photon imaging of microglia and synapses in the brains of live mice with single-cell genomics and CRISPR screens. This will help define microglia's role in experience-dependent synaptic refinement, a process thought to be disrupted in conditions like autism. In parallel, the team will use a maternal immune activation mouse model to identify mechanisms of refinement likely affected in neurodevelopmental disorders. They will also assess sex differences. New viral tools for studying microglia will be developed. The overall goal is to lay the foundation for new pharmacological strategies to treat neurodevelopmental disorders by restoring healthy microglial function during postnatal brain development. The award period is September 1, 2022 through August 31, 2025.

Generated 1/6/24, 7:57 PM