The National Institutes of Health (NIH) Office of the Director awarded a $1,345,424 Project Grant under the Trans-NIH Research Support program (CFDA 93.310) to the Regents of the University of Michigan. The grant, effective September 10, 2024 through September 9, 2027, aims to develop a novel genetically encoded "protein ticker tape" system that enables long-term, brain-wide recording of single-cell physiology in live mice without external interfacing. The technology will leverage...
The National Science Foundation's (NSF) Chemistry of Life Processes Program awarded a Project Grant of $698,869 to the University of Michigan to develop new molecular tools to study brain signaling-specific neuronal populations. The goal is to create a new class of reporters that can quickly label neurons activated during specific behaviors, enabling further study of the neural circuits underlying cognitive functions and behaviors. This 5-year project will utilize directed evolution and rational...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, is for the development and validation of micro-LED optoelectrode platforms to enable high-density, artifact-free neural modulation and recording in behaving animal models. The $556,525 award, effective June 1, 2025 through April 30, 2030, will support the Regents of the University of...
The U.S. National Institutes of Health (NIH) awarded a $1,671,116 Cooperative Agreement grant under the Trans-NIH Research Support (CFDA 93.310) program to The Washington University in St. Louis. The 3-year grant, running from September 2023 to August 2026, aims to develop a novel two-component optogenetic system for reversibly controlling the activity of user-defined synaptic connections between specific cell types in the brain. The project will involve engineering light-sensitive G...
The University of Michigan was awarded a $2.764 million Project Grant from the Department of Health and Human Services Assistant Secretary for Financial Resources under the Biomedical Research and Research Training program (CFDA 93.859) to conduct research on the in-situ architecture of membrane contact sites mediating organelle fission. The university will use novel microscopy techniques to visualize and determine the three-dimensional structure of endoplasmic reticulum-mitochondria-lysosome...
The National Institutes of Health's National Institute of Neurological Disorders and Stroke awarded a $3,045,502 Project Grant to the Regents of the University of Michigan on August 18, 2022 under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The grant funds the development of optical neural motes to enable high-density neural recording through intact dura in nonhuman primates. Specifically, the University of Michigan will design...
The University of Southern California was awarded a $2,689,528 Project Grant from the Department of Health and Human Services' National Institute of General Medical Sciences Biomedical Research and Training program (CFDA 93.859) to develop novel bio-orthogonal nanosensors. Over a three-year period ending August 2025, the University will create fluorine-based nanoparticles with dual functionalities to non-invasively sense and stimulate ionic neurotransmitters. Specifically, the nanoparticles will...
This federal Project Grant award from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) provides $1,988,947 to the Regents of the University of Michigan to develop a scalable high-plex pipeline for whole-brain proteomics profiling. The goal is to create a 100-plex antibody panel and novel ultra-speed light-sheet microscope and data management system to generate comprehensive proteomic atlases of the whole mouse brain across 6 postnatal...
The University of Texas Health Science Center at Houston (UTHealth) received a $3,145,118 Project Grant from the National Institute of Neurological Disorders and Stroke (NINDS) under the 21st Century Cures Act - Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative (CFDA 93.372). The grant aims to develop a new class of optogenetic tools based on natural potassium-selective channelrhodopsins (KCRs) that can precisely silence neuronal activity in both cell bodies and...
The Regents of the University of Michigan received a $137,586 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the 21st Century Cures Act - Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative (CFDA 93.372). The grant funds the development of a reconfigurable neural interface platform that can integrate multiple sensor modalities, including electrophysiological recording, neurostimulation, and physiochemical...