This $2,952,000 project grant from the Department of Health and Human Services National Institutes of Health Office of the Director will fund the development and application of novel technologies to track and record cell fate lineages at high resolution and throughput. Specifically, the Trustees of Dartmouth College will utilize innovative CRISPR systems, molecular recording tools, and improved lineage tracing to reconstruct annotated lineage trees mapping the developmental origins and probabilistic relationships between intestinal cell types in mouse embryonic stem cells and terminally differentiated cells. This work aims to provide new insights into cell fate plasticity and generate valuable recording mouse lines as a resource for the biomedical community. The funding falls under the Trans-NIH Research Support program (CFDA #93.310), which provides assistance awards and supplements across multiple offices in the NIH Office of the Director. The period of performance is from September 1, 2022 through August 31, 2025.
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